Persistent symptoms among survivors of hodgkin's disease: An explanatory model based on classical conditioning

Christine L. Cameron; David Cell; James E. Herndon; Alice B. Kornblith; Enid Zuckerman; Edward Henderson; Raymond B. Weiss; M. Robert Cooper; Richard T. Silver; Louis Leone; George P. Canellos; Bruce A. Peterson; Jimmie C. Holland

doi:10.1037/0278-6133.20.1.71

Persistent symptoms among survivors of hodgkin's disease: An explanatory model based on classical conditioning

Christine L. Cameron, David Cell, James E. Herndon, Alice B. Kornblith, Enid Zuckerman, Edward Henderson, Raymond B. Weiss, M. Robert Cooper, Richard T. Silver, Louis Leone, George P. Canellos, Bruce A. Peterson, Jimmie C. Holland

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

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Abstract

Persistent symptoms of nausea, distress, and vomiting triggered by reminders of cancer treatment were examined among 273 Hodgkin's disease survivors, 1 to 20 years posttreatment. Prevalence rates were high for distress and nausea but low for vomiting. Retrospective report of anticipatory symptoms during treatment was the strongest predictor of persistent symptoms, suggesting that treatment-induced symptoms are less likely to persist if conditioning does not occur initially. Time since treatment was also a significant predictor, with patients more recently treated more likely to experience persistent symptoms. Thus, an explanatory model based on classical conditioning theory successfully predicted presence of persistent symptoms. Symptoms also were associated with ongoing psychological distress, suggesting that quality of life is diminished among survivors with persistent symptoms. Recommendations for prevention and treatment of symptoms are discussed.

Original language	English (US)
Pages (from-to)	71-75
Number of pages	5
Journal	Health Psychology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1037/0278-6133.20.1.71
State	Published - 2001

Keywords

Anticipatory side effects
Classical conditioning
Hodgkin's disease
Nausea
Psychological distress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1037/0278-6133.20.1.71

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Cameron, C. L., Cell, D., Herndon, J. E., Kornblith, A. B., Zuckerman, E., Henderson, E., Weiss, R. B., Cooper, M. R., Silver, R. T., Leone, L., Canellos, G. P., Peterson, B. A., & Holland, J. C. (2001). Persistent symptoms among survivors of hodgkin's disease: An explanatory model based on classical conditioning. Health Psychology, 20(1), 71-75. https://doi.org/10.1037/0278-6133.20.1.71

Cameron, CL, Cell, D, Herndon, JE, Kornblith, AB, Zuckerman, E, Henderson, E, Weiss, RB, Cooper, MR, Silver, RT, Leone, L, Canellos, GP, Peterson, BA & Holland, JC 2001, 'Persistent symptoms among survivors of hodgkin's disease: An explanatory model based on classical conditioning', Health Psychology, vol. 20, no. 1, pp. 71-75. https://doi.org/10.1037/0278-6133.20.1.71

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title = "Persistent symptoms among survivors of hodgkin's disease: An explanatory model based on classical conditioning",

abstract = "Persistent symptoms of nausea, distress, and vomiting triggered by reminders of cancer treatment were examined among 273 Hodgkin's disease survivors, 1 to 20 years posttreatment. Prevalence rates were high for distress and nausea but low for vomiting. Retrospective report of anticipatory symptoms during treatment was the strongest predictor of persistent symptoms, suggesting that treatment-induced symptoms are less likely to persist if conditioning does not occur initially. Time since treatment was also a significant predictor, with patients more recently treated more likely to experience persistent symptoms. Thus, an explanatory model based on classical conditioning theory successfully predicted presence of persistent symptoms. Symptoms also were associated with ongoing psychological distress, suggesting that quality of life is diminished among survivors with persistent symptoms. Recommendations for prevention and treatment of symptoms are discussed.",

keywords = "Anticipatory side effects, Classical conditioning, Hodgkin's disease, Nausea, Psychological distress",

author = "Cameron, {Christine L.} and David Cell and Herndon, {James E.} and Kornblith, {Alice B.} and Enid Zuckerman and Edward Henderson and Weiss, {Raymond B.} and Cooper, {M. Robert} and Silver, {Richard T.} and Louis Leone and Canellos, {George P.} and Peterson, {Bruce A.} and Holland, {Jimmie C.}",

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AU - Cameron, Christine L.

AU - Cell, David

AU - Herndon, James E.

AU - Kornblith, Alice B.

AU - Zuckerman, Enid

AU - Henderson, Edward

AU - Weiss, Raymond B.

AU - Cooper, M. Robert

AU - Silver, Richard T.

AU - Leone, Louis

AU - Canellos, George P.

AU - Peterson, Bruce A.

AU - Holland, Jimmie C.

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AB - Persistent symptoms of nausea, distress, and vomiting triggered by reminders of cancer treatment were examined among 273 Hodgkin's disease survivors, 1 to 20 years posttreatment. Prevalence rates were high for distress and nausea but low for vomiting. Retrospective report of anticipatory symptoms during treatment was the strongest predictor of persistent symptoms, suggesting that treatment-induced symptoms are less likely to persist if conditioning does not occur initially. Time since treatment was also a significant predictor, with patients more recently treated more likely to experience persistent symptoms. Thus, an explanatory model based on classical conditioning theory successfully predicted presence of persistent symptoms. Symptoms also were associated with ongoing psychological distress, suggesting that quality of life is diminished among survivors with persistent symptoms. Recommendations for prevention and treatment of symptoms are discussed.

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KW - Classical conditioning

KW - Hodgkin's disease

KW - Nausea

KW - Psychological distress

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Persistent symptoms among survivors of hodgkin's disease: An explanatory model based on classical conditioning

Abstract

Keywords

UN SDGs

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