Persistent organic pollutants in adipose tissue should be considered in obesity research

Y. M. Lee, K. S. Kim, D. R. Jacobs, D. H. Lee

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Although low doses of persistent organic pollutants (POPs), strong lipophilic chemicals with long half-lives, have been linked to various endocrine, immune, nervous and reproductive system diseases, few obesity studies have considered adipose tissue as an important POPs exposure source. Because the toxicodynamics of POPs relate directly to the dynamics of adiposity, POPs might explain puzzling findings in obesity research. In two people exposed to the same amounts of environmental POPs, the one having more adipose tissue may be advantaged because POPs storage in adipose tissue can reduce burden on other critical organs. Therefore, adipose tissue can play a protective role against the POPs effects. However, two situations increase the POPs release from adipose tissue into the circulation, thereby increasing the risk that they will reach critical organs: (i) weight loss and (ii) insulin resistance. In contrast, weight gain reduces this possibility. Therefore, avoiding harmful health effects of POPs may mostly contradict conventional judgments about obesity and weight change. These contradictory situations can explain the obesity paradox, the adverse effects of intensive intentional weight loss and the protective effects of obesity against dementia. Future studies should consider that adipose tissue is widely contaminated with POPs in modern society.

Original languageEnglish (US)
Pages (from-to)129-139
Number of pages11
JournalObesity Reviews
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2017

Bibliographical note

Funding Information:
This study was supported by the Korean Health Technology R&D Project (HI13C0715), funded by the Ministry of Health and Welfare; and the Environmental Health Action Program (2016001370002), funded by the Korea Ministry of Environment of the Republic of Korea.

Keywords

  • Dementia
  • obesity paradox
  • persistent organic pollutants
  • weight loss

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