TY - JOUR
T1 - Peripheral vestibular pathology in Mondini dysplasia
AU - Kaya, Serdar
AU - Hızlı, Ömer
AU - Kaya, Fatıma Kübra
AU - Monsanto, Rafael Da Costa
AU - Paparella, Michael M.
AU - Cureoglu, Sebahattin
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives/Hypothesis: In this study, our objective was to histopathologically analyze the peripheral vestibular system in patients with Mondini dysplasia. Study Design: Comparative human temporal bone study. Methods: We assessed the sensory epithelium of the human vestibular system with a focus on the number of type I and type II hair cells, as well as the total number of hair cells. We compared those numbers in our Mondini dysplasia group versus our control group. Results: The loss of type I and type II hair cells in the cristae of the superior, lateral, and posterior semicircular canals, as well as in the saccular and utricular macula, was significantly higher in our Mondini dysplasia group than in our control group. The total number of hair cells significantly decreased in the cristae of the superior, lateral, and posterior semicircular canals, as well as in the saccular and utricular macula, in our Mondini dysplasia group. Conclusion: Loss of vestibular hair cells can lead to vestibular dysfunction in patients with Mondini dysplasia. Level of Evidence: NA Laryngoscope, 127:206–209, 2017.
AB - Objectives/Hypothesis: In this study, our objective was to histopathologically analyze the peripheral vestibular system in patients with Mondini dysplasia. Study Design: Comparative human temporal bone study. Methods: We assessed the sensory epithelium of the human vestibular system with a focus on the number of type I and type II hair cells, as well as the total number of hair cells. We compared those numbers in our Mondini dysplasia group versus our control group. Results: The loss of type I and type II hair cells in the cristae of the superior, lateral, and posterior semicircular canals, as well as in the saccular and utricular macula, was significantly higher in our Mondini dysplasia group than in our control group. The total number of hair cells significantly decreased in the cristae of the superior, lateral, and posterior semicircular canals, as well as in the saccular and utricular macula, in our Mondini dysplasia group. Conclusion: Loss of vestibular hair cells can lead to vestibular dysfunction in patients with Mondini dysplasia. Level of Evidence: NA Laryngoscope, 127:206–209, 2017.
KW - Mondini dysplasia
KW - crista
KW - histopathology
KW - human temporal bone
KW - lateral semicircular canal
KW - macula
KW - posterior semicircular canal
KW - saccule
KW - superior semicircular canal
KW - utricle
KW - vestibular hair cell
UR - http://www.scopus.com/inward/record.url?scp=84963865365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963865365&partnerID=8YFLogxK
U2 - 10.1002/lary.25995
DO - 10.1002/lary.25995
M3 - Article
C2 - 27075694
AN - SCOPUS:84963865365
VL - 127
SP - 206
EP - 209
JO - Laryngoscope
JF - Laryngoscope
SN - 0023-852X
IS - 1
ER -