Peripheral versus central nervous system APOE in Alzheimer's disease: Interplay across the blood-brain barrier

Dustin Chernick, Stephanie Ortiz-Valle, Angela Jeong, Wenhui Qu, Ling Li

Research output: Contribution to journalReview article

Abstract

The apolipoprotein E (APOE) ε4 allele has been demonstrated as the preeminent genetic risk factor for late onset Alzheimer's disease (AD), which comprises greater than 90% of all AD cases. The discovery of the connection between different APOE genotypes and AD risk in the early 1990s spurred three decades of intense and comprehensive research into the function of APOE in the normal and diseased brain. The importance of APOE in the periphery has been well established, due to its pivotal role in maintaining cholesterol homeostasis and cardiovascular health. The influence of vascular factors on brain function and AD risk has been extensively studied in recent years. As a major apolipoprotein regulating multiple molecular pathways beyond its canonical lipid-related functions in the periphery and the central nervous system, APOE represents a critical link between the two compartments, and may influence AD risk from both sides of the blood-brain barrier. This review discusses recent advances in understanding the different functions of APOE in the periphery and in the brain, and highlights several promising APOE-targeted therapeutic strategies for AD.

Original languageEnglish (US)
Article number134306
JournalNeuroscience Letters
Volume708
DOIs
StatePublished - Aug 24 2019

Fingerprint

Apolipoproteins E
Blood-Brain Barrier
Alzheimer Disease
Central Nervous System
Brain Diseases
Apolipoprotein E4
Apolipoproteins
Homeostasis
Alleles
Cholesterol
Genotype
Lipids
Health
Brain
Research

Keywords

  • APOE-targeted therapeutic strategies
  • Alzheimer's disease pathogenesis
  • Apolipoprotein E
  • Blood-brain barrier
  • Brain
  • Cognition
  • Inflammation
  • Periphery

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

Cite this

Peripheral versus central nervous system APOE in Alzheimer's disease : Interplay across the blood-brain barrier. / Chernick, Dustin; Ortiz-Valle, Stephanie; Jeong, Angela; Qu, Wenhui; Li, Ling.

In: Neuroscience Letters, Vol. 708, 134306, 24.08.2019.

Research output: Contribution to journalReview article

Chernick, Dustin ; Ortiz-Valle, Stephanie ; Jeong, Angela ; Qu, Wenhui ; Li, Ling. / Peripheral versus central nervous system APOE in Alzheimer's disease : Interplay across the blood-brain barrier. In: Neuroscience Letters. 2019 ; Vol. 708.
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