Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)

D. Jönsson; M. Orho-Melander; R. T. Demmer; G. Engström; O. Melander; B. Klinge; P. M. Nilsson

doi:10.1111/joim.12998

Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)

D. Jönsson, M. Orho-Melander, R. T. Demmer, G. Engström, O. Melander, B. Klinge, P. M. Nilsson

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods: The Malmö Offspring Study (MOS) is a population-based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malmö Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results: In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta-coefficient was 0.34 mm² (95% CI 0.16–0.52). Conclusion: Individuals within the highest quartile of periodontal pockets are expected to have 9 mm² larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	Journal of Internal Medicine
Volume	287
Issue number	3
DOIs	https://doi.org/10.1111/joim.12998
State	Published - Mar 1 2020

Bibliographical note

Funding Information:
MOS was supported by the Research Council of Sweden, the Heart‐ and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants – Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses ‐ biomedical scientists and nurses – Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingegärd Lundgren Svensson and the statistician Per‐Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden.

Funding Information:
MOS was supported by the Research Council of Sweden, the Heart- and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Sk?ne, the Crafoord Foundation, the Albert P?hlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants ? Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses - biomedical scientists and nurses ? Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingeg?rd Lundgren Svensson and the statistician Per-Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden.

Publisher Copyright:
© 2019 The Association for the Publication of the Journal of Internal Medicine

Keywords

atherosclerosis
carotid plaque
epidemiology
periodontal disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1111/joim.12998

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@article{245e62a1d94e49e1966004c0115cc528,

title = "Periodontal disease is associated with carotid plaque area: the Malm{\"o} Offspring Dental Study (MODS)",

abstract = "Background: Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods: The Malm{\"o} Offspring Study (MOS) is a population-based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malm{\"o} Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results: In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta-coefficient was 0.34 mm2 (95% CI 0.16–0.52). Conclusion: Individuals within the highest quartile of periodontal pockets are expected to have 9 mm2 larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.",

keywords = "atherosclerosis, carotid plaque, epidemiology, periodontal disease",

author = "D. J{\"o}nsson and M. Orho-Melander and Demmer, {R. T.} and G. Engstr{\"o}m and O. Melander and B. Klinge and Nilsson, {P. M.}",

note = "Funding Information: MOS was supported by the Research Council of Sweden, the Heart‐ and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Sk{\aa}ne, the Crafoord Foundation, the Albert P{\aa}hlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants – Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses ‐ biomedical scientists and nurses – Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingeg{\"a}rd Lundgren Svensson and the statistician Per‐Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden. Funding Information: MOS was supported by the Research Council of Sweden, the Heart- and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Sk?ne, the Crafoord Foundation, the Albert P?hlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants ? Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses - biomedical scientists and nurses ? Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingeg?rd Lundgren Svensson and the statistician Per-Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden. Publisher Copyright: {\textcopyright} 2019 The Association for the Publication of the Journal of Internal Medicine",

year = "2020",

month = mar,

day = "1",

doi = "10.1111/joim.12998",

language = "English (US)",

volume = "287",

pages = "301--309",

journal = "Journal of Internal Medicine",

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TY - JOUR

T1 - Periodontal disease is associated with carotid plaque area

T2 - the Malmö Offspring Dental Study (MODS)

AU - Jönsson, D.

AU - Orho-Melander, M.

AU - Demmer, R. T.

AU - Engström, G.

AU - Melander, O.

AU - Klinge, B.

AU - Nilsson, P. M.

N1 - Funding Information: MOS was supported by the Research Council of Sweden, the Heart‐ and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants – Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses ‐ biomedical scientists and nurses – Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingegärd Lundgren Svensson and the statistician Per‐Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden. Funding Information: MOS was supported by the Research Council of Sweden, the Heart- and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Sk?ne, the Crafoord Foundation, the Albert P?hlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants ? Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses - biomedical scientists and nurses ? Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingeg?rd Lundgren Svensson and the statistician Per-Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden. Publisher Copyright: © 2019 The Association for the Publication of the Journal of Internal Medicine

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods: The Malmö Offspring Study (MOS) is a population-based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malmö Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results: In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta-coefficient was 0.34 mm2 (95% CI 0.16–0.52). Conclusion: Individuals within the highest quartile of periodontal pockets are expected to have 9 mm2 larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.

AB - Background: Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods: The Malmö Offspring Study (MOS) is a population-based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malmö Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results: In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta-coefficient was 0.34 mm2 (95% CI 0.16–0.52). Conclusion: Individuals within the highest quartile of periodontal pockets are expected to have 9 mm2 larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.

KW - atherosclerosis

KW - carotid plaque

KW - epidemiology

KW - periodontal disease

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Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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