Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS)

D. Jönsson, M. Orho-Melander, R. T. Demmer, G. Engström, O. Melander, B. Klinge, P. M. Nilsson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population-based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA). Methods: The Malmö Offspring Study (MOS) is a population-based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malmö Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters. Results: In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53 years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11–2.78). In a linear model with TPA as dependent and number of periodontal pockets ≥ 4 mm as independent variable, the adjusted beta-coefficient was 0.34 mm2 (95% CI 0.16–0.52). Conclusion: Individuals within the highest quartile of periodontal pockets are expected to have 9 mm2 larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.

Original languageEnglish (US)
Pages (from-to)301-309
Number of pages9
JournalJournal of Internal Medicine
Volume287
Issue number3
DOIs
StatePublished - Mar 1 2020

Bibliographical note

Funding Information:
MOS was supported by the Research Council of Sweden, the Heart‐ and Lung Foundation, and the Region Skane County Council (ALF) grant to PM Nilsson. MODS was supported by grants from Oral Health Related Research by Region Skåne, the Crafoord Foundation, the Albert Påhlsson Foundation and the Swedish Dental Service of Skane. The authors would like to extend their gratitude to the following people working within the MODS study since 2013; dentists who examined the participants – Liselott Bennvid, Elisabeth Hansson, Demir Cirgic, Elisabeth Larsson and staff helping out in the lab dental nurses ‐ biomedical scientists and nurses – Johanna Karlsson, Anna Hallberg, Christina Neroth, Anders Holm and Ingegärd Lundgren Svensson and the statistician Per‐Erik Isberg (Institute of Statistics, Lund University, Lund). We are also profoundly grateful to the MODS participants for their participation in this research. The manuscript has been handled by an external editor, Professor Olov Wiklund, Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska University Hospital Gothenburg, Sweden.

Publisher Copyright:
© 2019 The Association for the Publication of the Journal of Internal Medicine

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • atherosclerosis
  • carotid plaque
  • epidemiology
  • periodontal disease

PubMed: MeSH publication types

  • Journal Article
  • Observational Study
  • Research Support, Non-U.S. Gov't

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