Periodontal Bacteria and Prediabetes Prevalence in ORIGINS

R. T. Demmer, D. R. Jacobs, R. Singh, A. Zuk, M. Rosenbaum, P. N. Papapanou, M. Desvarieux

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Periodontitis and type 2 diabetes mellitus are known to be associated. The relationship between periodontal microbiota and early diabetes risk has not been studied. We investigated the association between periodontal bacteria and prediabetes prevalence among diabetes-free adults. ORIGINS (the Oral Infections, Glucose Intolerance and Insulin Resistance Study) cross sectionally enrolled 300 diabetes-free adults aged 20 to 55 y (mean ± SD, 34 ± 10 y; 77% female). Prediabetes was defined as follows: 1) hemoglobin A1c values ranging from 5.7% to 6.4% or 2) fasting plasma glucose ranging from 100 to 125 mg/dL. In 1,188 subgingival plaque samples, 11 bacterial species were assessed at baseline, including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Actinomyces naeslundii. Full-mouth clinical periodontal examinations were performed, and participants were defined as having no/mild periodontitis vs. moderate/severe periodontitis per the definition of the Centers for Disease Control and Prevention / American Academy of Periodontology. Modified Poisson regression evaluated prediabetes prevalence across bacterial tertiles. Prevalence ratios and 95% confidence intervals for third vs. first tertiles are presented. All analyses were adjusted for cardiometabolic risk factors. All results presented currently arise from the baseline cross section. Prediabetes prevalence was 18%, and 58% of participants had moderate/severe periodontitis. Prevalence ratios (95% confidence intervals) summarizing associations between bacterial levels and prediabetes were as follows: A. actinomycetemcomitans, 2.48 (1.34, 4.58), P = 0.004; P. gingivalis, 3.41 (1.78, 6.58), P = 0.0003; T. denticola, 1.99 (0.992, 4.00), P = 0.052; T. forsythia, 1.95 (1.0, 3.84), P = 0.05; A. naeslundii, 0.46 (0.25, 0.85), P = 0.01. The prevalence ratio for prediabetes among participants with moderate/severe vs. no/mild periodontitis was 1.47 (0.78, 2.74), P = 0.23. Higher colonization levels of specific periodontal microbiota are associated with higher prediabetes prevalence among diabetes-free adults

Original languageEnglish (US)
Pages (from-to)201S-211S
JournalJournal of dental research
Volume94
DOIs
StatePublished - Sep 24 2015
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by grants from the National Institutes of Health (R00 DE018739, R21 DE022422) to Dr. Demmer. Dr. Demmer also received funding from a Calderone Research Award, Mailman School of Public Health, and a Pilot & Feasibility Award from the Diabetes and Endocrinology Research Center, College of Physicians and Surgeons (DK-63608). This publication was supported by the National Center for Advancing Translational Sciences, National Institutes of Health (grant UL1 TR000040), formerly the National Center for Research Resources (grant UL1 RR024156). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health .

Keywords

  • diabetes
  • epidemiology
  • impaired glucose regulation
  • infection
  • microbiota
  • periodontitis

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