Abstract
Three-dimensionally ordered macroporous materials containing the bioceramic hydroxyapatite as well as other calcium phosphate and carbonate phases have been synthesized using close-packed poly(methyl methacrylate) latex spheres (256-375 nm diameter) as templates. The interstitial spaces of the colloidal crystal were penetrated by a water/alcohol cosolvent solution of calcium nitrate and phosphoric acid. Calcination in the range 475-1000°C removed the polymer and promoted crystallization of calcium phosphate phases in the pore walls. The materials were characterized by powder X-ray diffraction, FT-IR spectroscopy, and SEM. The best combination of composition and three-dimensional order was found in a crystalline hydroxyapatite/tricalcium phosphate templated with 375-nm spheres and calcined at 700°C. An in vitro antibiotic drug release application was tested using this product.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3326-3331 |
| Number of pages | 6 |
| Journal | Chemistry of Materials |
| Volume | 14 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2002 |
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