Periodic macroporous hydroxyapatite-containing calcium phosphates

Brian J. Melde, Andreas Stein

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Three-dimensionally ordered macroporous materials containing the bioceramic hydroxyapatite as well as other calcium phosphate and carbonate phases have been synthesized using close-packed poly(methyl methacrylate) latex spheres (256-375 nm diameter) as templates. The interstitial spaces of the colloidal crystal were penetrated by a water/alcohol cosolvent solution of calcium nitrate and phosphoric acid. Calcination in the range 475-1000°C removed the polymer and promoted crystallization of calcium phosphate phases in the pore walls. The materials were characterized by powder X-ray diffraction, FT-IR spectroscopy, and SEM. The best combination of composition and three-dimensional order was found in a crystalline hydroxyapatite/tricalcium phosphate templated with 375-nm spheres and calcined at 700°C. An in vitro antibiotic drug release application was tested using this product.

Original languageEnglish (US)
Pages (from-to)3326-3331
Number of pages6
JournalChemistry of Materials
Volume14
Issue number8
DOIs
StatePublished - Aug 2002

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