Periodic fluctuations in synaptic transmission and enhancement of transmission in hippocampal slices

Walter C. Low, Spencer L. BeMent, David Whitehorn

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The properties of the synchronously activated radiatum fiber-CA1 synaptic population were examined with the in vitro hippocampal slice preparation. Periodic fluctuations in synaptic transmission and in the enhancement of synaptic transmission were observed with periods ranging from 8 to 20 s. Such periodic fluctuations did not arise from fluctuations in afferent radiatum fiber activity. The period and amplitude of the cyclic variations in the enhancement of synaptic transmission were found to be altered with repeated electrical stimulation of the radiatum fibers. These results reflect cooperative synaptic actions which must be taken into consideration in the delineation of the mechanisms of potentiation.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalBrain Research
Volume231
Issue number2
DOIs
StatePublished - Jan 14 1982

Keywords

  • hippocampal slices
  • periodic fluctuations
  • synaptic transmission

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