Perinatal complications and genetic loading in schizophrenia: Preliminary findings

Steven B. Schwarzkopf, Henry A. Nasrallah, Stephen C. Olson, Jeffrey A. Coffman, Judy A. McLaughlin

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

History of perinatal complications (PCs) and first degree family history (FH) of psychiatric illness were examined in groups of schizophrenic/ schizoaffective (n = 21) and bipolar (n = 10) patients. PCs were significantly more frequent in the schizophrenic and schizoaffective patients than in bipolar patients. An inverse relationship was found between PCs and FH status, with FH-positive patients having significantly fewer PCs than the FH-negative group. This relationship persisted when the bipolar patients were excluded. Findings emphasize the etiological importance of genetics and perinatal events in the psychoses, and support the validity of a familial/sporadic distinction.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalPsychiatry Research
Volume27
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

Keywords

  • Schizophrenia
  • bipolar
  • family history
  • perinatal complications

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