Perilipins at a glance

Charles P Najt, Mahima Devarajan, Douglas G. Mashek

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy metabolism, membrane synthesis and production of lipid-derived signaling molecules. While compositional differences in the phospholipid monolayer or neutral lipid core of LDs impact their metabolism and function, the proteome of LDs has emerged as a major influencer in all aspects of LD biology. The perilipins (PLINs) are the most studied and abundant proteins residing on the LD surface. This Cell Science at a Glance and the accompanying poster summarize our current knowledge of the common and unique features of the mammalian PLIN family of proteins, the mechanisms through which they affect cell metabolism and signaling, and their links to disease.

Original languageEnglish (US)
Article numberjcs259501
JournalJournal of cell science
Volume135
Issue number5
DOIs
StatePublished - Mar 2022

Bibliographical note

Publisher Copyright:
© 2022. Published by The Company of Biologists Ltd.

Keywords

  • Lipid droplets
  • Lipid metabolism
  • Lipid signaling
  • Perilipins

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

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