Perfusion preservation of the donor heart: Basic science to pre-clinical

Andrew L. Rivard, Robert Gallegos, Irene M. Ogden, Richard W. Bianco

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of preclinical evaluation necessary for regulatory approval.

Original languageEnglish (US)
Pages (from-to)140-148
Number of pages9
JournalJournal of Extra-Corporeal Technology
Volume41
Issue number3
StatePublished - Sep 1 2009

Keywords

  • Cardiac transplant
  • Donor heart
  • Myocardial protection

Fingerprint

Dive into the research topics of 'Perfusion preservation of the donor heart: Basic science to pre-clinical'. Together they form a unique fingerprint.

Cite this