Abstract
Purpose: To determine the diagnostic utility of posttreatment surveillance whole-body 18 F-FDG PET/CT in detecting local tumor recurrence (R), regional lymph-node metastasis (LM), and distant metastasis (DM) in asymptomatic sinonasal cancer patients. Methods: Eighty consecutive patients (53 men, 27 women; mean age, 60 years; range, 28–92 years) who had undergone 197 posttreatment whole-body 18 F-FDG PET/CT examinations for sinonasal malignancies between January 2009 and August 2017 were retrospectively reviewed. 18 F-FDG PET/CT findings were categorized as positive or negative for R, LM, and DM, separately. Outcomes of 18 F-FDG PET/CT scans were compared with the final diagnosis confirmed by histological analysis or follow-up period for a minimum 12 months. The diagnostic accuracy of scans was calculated for each site using contingency tables. Impact on the management of 18 F-FDG PET/CT examinations was additionally evaluated. Results: 18 F-FDG PET/CT scans identified 37/44 of local recurrences, 21/23 of LMs, and 30/37 of DMs. For local recurrence, sensitivity, specificity, positive predictive value, and negative predictive value were 84% (68–97%), 95% (80–100%), 84% (68–97%), and 95% (80–100%), respectively. For LM, the respective values were 91% (75–100%), 99% (83–100%), 91% (75–100%), and 99% (83–100%). For DM, the values were 81% (64–97%), 99% (85–100%), 97% (81–100%), and 96% (81–100%), respectively. 18 F-FDG PET/CT accounted for a change in management of 85% patients with recurrences. Conclusions: Whole-body 18 F-FDG PET/CT is a suitable surveillance tool for sinonasal malignancies in detecting locoregional and distant recurrences in asymptomatic patients without any evidence of recurrence on regular follow-up and endoscopy during the posttreatment period.
Original language | English (US) |
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Pages (from-to) | 847-855 |
Number of pages | 9 |
Journal | European Archives of Oto-Rhino-Laryngology |
Volume | 276 |
Issue number | 3 |
DOIs | |
State | Published - Mar 14 2019 |
Bibliographical note
Publisher Copyright:© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords
- F-FDG PET/CT
- Posttreatment
- Recurrence
- Sinonasal malignancies
- Surveillance
PubMed: MeSH publication types
- Journal Article