Performance of FRAX in clinical practice according to sex and osteoporosis definitions: the Manitoba BMD registry

W. D. Leslie, S. R. Majumdar, S. N. Morin, L. M. Lix, J. T. Schousboe, K. E. Ensrud, H. Johansson, E. V. McCloskey, J. A. Kanis

Research output: Contribution to journalArticle

Abstract

Summary: Among 62,275 women and 6455 men, FRAX stratified risk for incident major osteoporotic fracture (MOF) and incident hip fracture (HF) without sex interaction. Performance was good in those with osteoporosis regardless of how this was defined. Introduction: Some studies have reported that FRAX performance differs according to sex and/or osteoporosis definitions. We evaluated whether the performance of FRAX to predict incident MOF and HF in women and men was affected by the presence or absence of osteoporosis defined by World Health Organization (WHO) or National Osteoporosis Foundation (NOF) criteria. Methods: We studied women and men age ≥ 40 years with baseline hip and spine DXA scans (1996–2013). Individuals were classified into four non-overlapping subgroups: osteoporosis by WHO criteria, osteoporosis exclusively by NOF criteria, high fracture risk by FRAX (MOF ≥ 20% or HF ≥ 3%, without osteoporosis), and low fracture risk (MOF OpenSPiltSPi 20% and HF OpenSPiltSPi 3% without osteoporosis). In each subgroup, we evaluated stratification (hazard ratios [HR]) and calibration (observed vs predicted 10-year fracture probability) for incident fracture. Results: The population included 62,275 women (5345 MOF and 1471 HF) and 6455 men (405 MOF and 108 HF). FRAX scores were strongly predictive of MOF (HR per SD: women 2.12, 95% CI 2.06–2.18; men 1.89, 95% CI 1.73–2.08; sex interaction p value = 0.97) and HF (women 4.78, 95% CI 4.44–5.14; men 4.20, 95% CI 3.22–5.49; sex interaction p value = 0.71). FRAX scores gave similar HRs for MOF among the four subgroups (subgroup interaction p value 0.34 for women, 0.22 for men). Observed versus predicted 10-year MOF and HF probability for the defined subgroups demonstrated a high level of concordance for women and men (all r 2 ≥ 0.9). Conclusions: FRAX was a strong and consistent predictor of MOF and HF in both women and men and performed well in those with osteoporosis whether defined by WHO or NOF criteria.

Original languageEnglish (US)
Pages (from-to)759-767
Number of pages9
JournalOsteoporosis International
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2018

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Manitoba
Osteoporotic Fractures
Osteoporosis
Hip Fractures
Registries
Photon Absorptiometry
Calibration
Hip
Spine

Keywords

  • DXA
  • FRAX
  • Fracture risk assessment
  • Osteoporosis

Cite this

Performance of FRAX in clinical practice according to sex and osteoporosis definitions : the Manitoba BMD registry. / Leslie, W. D.; Majumdar, S. R.; Morin, S. N.; Lix, L. M.; Schousboe, J. T.; Ensrud, K. E.; Johansson, H.; McCloskey, E. V.; Kanis, J. A.

In: Osteoporosis International, Vol. 29, No. 3, 01.03.2018, p. 759-767.

Research output: Contribution to journalArticle

Leslie, WD, Majumdar, SR, Morin, SN, Lix, LM, Schousboe, JT, Ensrud, KE, Johansson, H, McCloskey, EV & Kanis, JA 2018, 'Performance of FRAX in clinical practice according to sex and osteoporosis definitions: the Manitoba BMD registry', Osteoporosis International, vol. 29, no. 3, pp. 759-767. https://doi.org/10.1007/s00198-018-4415-y
Leslie, W. D. ; Majumdar, S. R. ; Morin, S. N. ; Lix, L. M. ; Schousboe, J. T. ; Ensrud, K. E. ; Johansson, H. ; McCloskey, E. V. ; Kanis, J. A. / Performance of FRAX in clinical practice according to sex and osteoporosis definitions : the Manitoba BMD registry. In: Osteoporosis International. 2018 ; Vol. 29, No. 3. pp. 759-767.
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abstract = "Summary: Among 62,275 women and 6455 men, FRAX stratified risk for incident major osteoporotic fracture (MOF) and incident hip fracture (HF) without sex interaction. Performance was good in those with osteoporosis regardless of how this was defined. Introduction: Some studies have reported that FRAX performance differs according to sex and/or osteoporosis definitions. We evaluated whether the performance of FRAX to predict incident MOF and HF in women and men was affected by the presence or absence of osteoporosis defined by World Health Organization (WHO) or National Osteoporosis Foundation (NOF) criteria. Methods: We studied women and men age ≥ 40 years with baseline hip and spine DXA scans (1996–2013). Individuals were classified into four non-overlapping subgroups: osteoporosis by WHO criteria, osteoporosis exclusively by NOF criteria, high fracture risk by FRAX (MOF ≥ 20{\%} or HF ≥ 3{\%}, without osteoporosis), and low fracture risk (MOF OpenSPiltSPi 20{\%} and HF OpenSPiltSPi 3{\%} without osteoporosis). In each subgroup, we evaluated stratification (hazard ratios [HR]) and calibration (observed vs predicted 10-year fracture probability) for incident fracture. Results: The population included 62,275 women (5345 MOF and 1471 HF) and 6455 men (405 MOF and 108 HF). FRAX scores were strongly predictive of MOF (HR per SD: women 2.12, 95{\%} CI 2.06–2.18; men 1.89, 95{\%} CI 1.73–2.08; sex interaction p value = 0.97) and HF (women 4.78, 95{\%} CI 4.44–5.14; men 4.20, 95{\%} CI 3.22–5.49; sex interaction p value = 0.71). FRAX scores gave similar HRs for MOF among the four subgroups (subgroup interaction p value 0.34 for women, 0.22 for men). Observed versus predicted 10-year MOF and HF probability for the defined subgroups demonstrated a high level of concordance for women and men (all r 2 ≥ 0.9). Conclusions: FRAX was a strong and consistent predictor of MOF and HF in both women and men and performed well in those with osteoporosis whether defined by WHO or NOF criteria.",
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AU - Leslie, W. D.

AU - Majumdar, S. R.

AU - Morin, S. N.

AU - Lix, L. M.

AU - Schousboe, J. T.

AU - Ensrud, K. E.

AU - Johansson, H.

AU - McCloskey, E. V.

AU - Kanis, J. A.

PY - 2018/3/1

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N2 - Summary: Among 62,275 women and 6455 men, FRAX stratified risk for incident major osteoporotic fracture (MOF) and incident hip fracture (HF) without sex interaction. Performance was good in those with osteoporosis regardless of how this was defined. Introduction: Some studies have reported that FRAX performance differs according to sex and/or osteoporosis definitions. We evaluated whether the performance of FRAX to predict incident MOF and HF in women and men was affected by the presence or absence of osteoporosis defined by World Health Organization (WHO) or National Osteoporosis Foundation (NOF) criteria. Methods: We studied women and men age ≥ 40 years with baseline hip and spine DXA scans (1996–2013). Individuals were classified into four non-overlapping subgroups: osteoporosis by WHO criteria, osteoporosis exclusively by NOF criteria, high fracture risk by FRAX (MOF ≥ 20% or HF ≥ 3%, without osteoporosis), and low fracture risk (MOF OpenSPiltSPi 20% and HF OpenSPiltSPi 3% without osteoporosis). In each subgroup, we evaluated stratification (hazard ratios [HR]) and calibration (observed vs predicted 10-year fracture probability) for incident fracture. Results: The population included 62,275 women (5345 MOF and 1471 HF) and 6455 men (405 MOF and 108 HF). FRAX scores were strongly predictive of MOF (HR per SD: women 2.12, 95% CI 2.06–2.18; men 1.89, 95% CI 1.73–2.08; sex interaction p value = 0.97) and HF (women 4.78, 95% CI 4.44–5.14; men 4.20, 95% CI 3.22–5.49; sex interaction p value = 0.71). FRAX scores gave similar HRs for MOF among the four subgroups (subgroup interaction p value 0.34 for women, 0.22 for men). Observed versus predicted 10-year MOF and HF probability for the defined subgroups demonstrated a high level of concordance for women and men (all r 2 ≥ 0.9). Conclusions: FRAX was a strong and consistent predictor of MOF and HF in both women and men and performed well in those with osteoporosis whether defined by WHO or NOF criteria.

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