Performance of a Commercial, Type-Specific Enzyme-Linked Immunosorbent Assay for Detection of Herpes Simplex Virus Type 2-Specific Antibodies in Ugandans

Oliver Laeyendecker, Charla Henson, Ronald H. Gray, Ruby H.N. Nguyen, Bobbi Jo Horne, Maria J. Wawer, David Serwadda, Noah Kiwanuka, Rhoda Ashley Morrow, Wayne Hogrefe, Thomas C. Quinn

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Two hundred forty-eight human immunodeficiency virus (HIV)-positive and 496 HIV-negative subjects in Uganda were tested by HerpeSelect herpes simplex virus type 2 enzyme-linked immunosorbent assay (ELISA) and Western blotting to optimize the ELISA for use in this population. A higher index cutoff value was required for optimal sensitivity and specificity, and overall performance of the assay was not affected by HIV status.

Original languageEnglish (US)
Pages (from-to)1794-1796
Number of pages3
JournalJournal of clinical microbiology
Volume42
Issue number4
DOIs
StatePublished - Apr 2004

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