Performance enhancement of the RatCAP awake rat brain PET system

P. Vaska, C. Woody, D. Schlyer, V. Radeka, P. O'Connor, S. J. Park, J. F. Pratte, S. Junnarkar, M. Purschke, S. Southekal, S. Stoll, W. Schiffer, D. Lee, J. Neill, D. Wharton, N. Myers, S. Wiley, A. Kandasamy, J. Fried, S. KrishnamoorthyA. Kriplani, S. Maramraju, R. Lecomte, R. Fontaine

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The first full prototype of the RatCAP PET system, designed to image the brain of a rat while conscious, has been completed. Initial results demonstrated excellent spatial resolution, 1.8 mm FWHM with filtered backprojection and <1.5 mm FWHM with a Monte Carlo based MLEM method. However, noise equivalent countrate studies indicated the need for better timing to mitigate the effect of randoms. Thus, the front-end ASIC has been redesigned to minimize time walk, an accurate coincidence time alignment method has been implemented, and a variance reduction technique for the randoms is being developed. To maximize the quantitative capabilities required for neuroscience, corrections are being implemented and validated for positron range and photon noncollinearity, scatter (including outside the field of view), attenuation, randoms, and detector efficiency (deadtime is negligible). In addition, a more robust and compact PCI-based optical data acquisition system has been built to replace the original VME-based system while retaining the linux-based data processing and image reconstruction codes. Finally, a number of new animal imaging experiments have been carried out to demonstrate the performance of the RatCAP in real imaging situations, including an F-18 fluoride bone scan, a C-11 raclopride scan, and a dynamic C-11 methamphetamine scan.

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2443-2446
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - Jan 1 2006
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

Fingerprint Dive into the research topics of 'Performance enhancement of the RatCAP awake rat brain PET system'. Together they form a unique fingerprint.

Cite this