Perfluoroheptane-Loaded Hollow Gold Nanoshells Reduce Nanobubble Threshold Flux

Jeong Eun Shin, Maria O. Ogunyankin, Joseph A. Zasadzinski

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The threshold flux for nanobubble formation and liposome rupture is reduced by 50–60% by adding a liquid mixture of tetradecanol and perfluoroheptane to the interior cavity of 40 nm diameter hollow gold nanoshells (HGN), and allowing the tetradecanol to solidify to hold the perfluoroheptane in place. On absorption of picosecond pulses of near-infrared light, the perfluoroheptane vaporizes to initiate cavitation-like nanobubbles as the HGN temperature increases. The lower spinodal temperature and heat capacity of perfluoroheptane relative to water causes the threshold flux for nanobubble formation to decrease. The perfluoroheptane-containing HGN can be linked via thiol–PEG–lipid tethers to carboxyfluorescein-containing liposomes and shows a similar decreased flux necessary for liposome contents release.

Original languageEnglish (US)
Article number1804476
JournalSmall
Volume15
Issue number7
DOIs
StatePublished - Feb 15 2019

Bibliographical note

Funding Information:
The authors thank Matthew Quan and Vivian Ferry for calculating the extinction curves in Figure E. This project was supported by grant RMM 102516 007 from Regenerative Medicine Minnesota, the Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME) and a grant from the Institute for Engineering in Medicine of the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program.

Funding Information:
The authors thank Matthew Quan and Vivian Ferry for calculating the extinction curves in Figure 1E. This project was supported by grant RMM 102516 007 from Regenerative Medicine Minnesota, the Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME) and a grant from the Institute for Engineering in Medicine of the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program.

Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • liposomes
  • near-infrared light
  • plasmon resonance
  • spinodal
  • threshold flux

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