Perfluoroheptane-Loaded Hollow Gold Nanoshells Reduce Nanobubble Threshold Flux

Jeong Eun Shin; Maria O. Ogunyankin; Joseph A. Zasadzinski

doi:10.1002/smll.201804476

Perfluoroheptane-Loaded Hollow Gold Nanoshells Reduce Nanobubble Threshold Flux

Jeong Eun Shin, Maria O. Ogunyankin, Joseph A. Zasadzinski

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The threshold flux for nanobubble formation and liposome rupture is reduced by 50–60% by adding a liquid mixture of tetradecanol and perfluoroheptane to the interior cavity of 40 nm diameter hollow gold nanoshells (HGN), and allowing the tetradecanol to solidify to hold the perfluoroheptane in place. On absorption of picosecond pulses of near-infrared light, the perfluoroheptane vaporizes to initiate cavitation-like nanobubbles as the HGN temperature increases. The lower spinodal temperature and heat capacity of perfluoroheptane relative to water causes the threshold flux for nanobubble formation to decrease. The perfluoroheptane-containing HGN can be linked via thiol–PEG–lipid tethers to carboxyfluorescein-containing liposomes and shows a similar decreased flux necessary for liposome contents release.

Original language	English (US)
Article number	1804476
Journal	Small
Volume	15
Issue number	7
DOIs	https://doi.org/10.1002/smll.201804476
State	Published - Feb 15 2019

Bibliographical note

Funding Information:
The authors thank Matthew Quan and Vivian Ferry for calculating the extinction curves in Figure E. This project was supported by grant RMM 102516 007 from Regenerative Medicine Minnesota, the Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME) and a grant from the Institute for Engineering in Medicine of the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program.

Funding Information:
The authors thank Matthew Quan and Vivian Ferry for calculating the extinction curves in Figure 1E. This project was supported by grant RMM 102516 007 from Regenerative Medicine Minnesota, the Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME) and a grant from the Institute for Engineering in Medicine of the University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program.

Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

liposomes
near-infrared light
plasmon resonance
spinodal
threshold flux

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10.1002/smll.201804476

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abstract = "The threshold flux for nanobubble formation and liposome rupture is reduced by 50–60% by adding a liquid mixture of tetradecanol and perfluoroheptane to the interior cavity of 40 nm diameter hollow gold nanoshells (HGN), and allowing the tetradecanol to solidify to hold the perfluoroheptane in place. On absorption of picosecond pulses of near-infrared light, the perfluoroheptane vaporizes to initiate cavitation-like nanobubbles as the HGN temperature increases. The lower spinodal temperature and heat capacity of perfluoroheptane relative to water causes the threshold flux for nanobubble formation to decrease. The perfluoroheptane-containing HGN can be linked via thiol–PEG–lipid tethers to carboxyfluorescein-containing liposomes and shows a similar decreased flux necessary for liposome contents release.",

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Perfluoroheptane-Loaded Hollow Gold Nanoshells Reduce Nanobubble Threshold Flux

Abstract

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