Peptides as central regulators of feeding

J. E. Morley, A. S. Levine, B. A. Gosnell, D. D. Krahn

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

During the past decade there has been an increased awareness of the role peptides play as neuromodulators. In this article we review the available data on peptides as central regulators of food ingestion. We stress the possible problems of non-specific effects. We stress that whereas many peptides decrease feeding after central injection, only two families of peptides have been shown to increase feeding after central injection. These are the opioid family and the pancreatic polypeptide-neuropeptide Y family. The putative role of corticotropin releasing factor as the mediator of norepinephrine and serotonin effects on feeding is discussed.

Original languageEnglish (US)
Pages (from-to)511-519
Number of pages9
JournalBrain Research Bulletin
Volume14
Issue number6
DOIs
StatePublished - Jun 1985

Keywords

  • Bombesin
  • Calcitonin
  • Cholecystokinin
  • Corticotropin releasing factor
  • Dynorphin
  • Food intake
  • Neuropeptide Y
  • Peptide YY

Fingerprint Dive into the research topics of 'Peptides as central regulators of feeding'. Together they form a unique fingerprint.

Cite this