Peptides and feeding

John E. Morley, Allen S. Levine, Blake A. Gosnell, James E. Mitchell, Dean D. Krahn, Steven E. Nizielski

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated-a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in (1) the anorexia of aging, (2) drinking elicited by feeding and (3) as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
Issue numberSUPPL. 2
StatePublished - 1985

Bibliographical note

Funding Information:
We thankJ o Ann Phillipsf or excellenst ecretariaals sistance, The researchin this manuscripwt as supportedb y the Veterans Administration.


  • Anorexia
  • Appetite modulation
  • Peptides
  • Ventromedial hypothalamic lesions


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