Peptides and feeding

John E. Morley; Allen S. Levine; Blake A. Gosnell; James E. Mitchell; Dean D. Krahn; Steven E. Nizielski

doi:10.1016/0196-9781(85)90153-6

Peptides and feeding

John E. Morley, Allen S. Levine, Blake A. Gosnell, James E. Mitchell, Dean D. Krahn, Steven E. Nizielski

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated-a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in (1) the anorexia of aging, (2) drinking elicited by feeding and (3) as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.

Original language	English (US)
Pages (from-to)	181-192
Number of pages	12
Journal	Peptides
Volume	6
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/0196-9781(85)90153-6
State	Published - 1985

Bibliographical note

Funding Information:
We thankJ o Ann Phillipsf or excellenst ecretariaals sistance, The researchin this manuscripwt as supportedb y the Veterans Administration.

Keywords

Anorexia
Appetite modulation
Peptides
Ventromedial hypothalamic lesions

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title = "Peptides and feeding",

abstract = "This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated-a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in (1) the anorexia of aging, (2) drinking elicited by feeding and (3) as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.",

keywords = "Anorexia, Appetite modulation, Peptides, Ventromedial hypothalamic lesions",

author = "Morley, {John E.} and Levine, {Allen S.} and Gosnell, {Blake A.} and Mitchell, {James E.} and Krahn, {Dean D.} and Nizielski, {Steven E.}",

note = "Funding Information: We thankJ o Ann Phillipsf or excellenst ecretariaals sistance, The researchin this manuscripwt as supportedb y the Veterans Administration.",

year = "1985",

doi = "10.1016/0196-9781(85)90153-6",

language = "English (US)",

volume = "6",

pages = "181--192",

journal = "Peptides",

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TY - JOUR

T1 - Peptides and feeding

AU - Morley, John E.

AU - Levine, Allen S.

AU - Gosnell, Blake A.

AU - Mitchell, James E.

AU - Krahn, Dean D.

AU - Nizielski, Steven E.

N1 - Funding Information: We thankJ o Ann Phillipsf or excellenst ecretariaals sistance, The researchin this manuscripwt as supportedb y the Veterans Administration.

PY - 1985

Y1 - 1985

N2 - This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated-a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in (1) the anorexia of aging, (2) drinking elicited by feeding and (3) as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.

AB - This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated-a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in (1) the anorexia of aging, (2) drinking elicited by feeding and (3) as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.

KW - Anorexia

KW - Appetite modulation

KW - Peptides

KW - Ventromedial hypothalamic lesions

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JO - Peptides

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SN - 0196-9781

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Peptides and feeding

Abstract

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Keywords

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