Peptidergic control of insulin-induced feeding

Allen S. Levine, John E. Morley

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Subcutaneous administration of insulin (10 U/kg) produced hypoglycemia in rats with a concomitant induction of feeding. The opiate antagonist naloxone failed to alter food ingestion following insulin administration when quantitated over a 3-hour period; however, naloxone (20 mg/kg) significantly suppressed eating during the first hour of the study. Starvation-induced feeding was markedly suppressed by relatively low doses of naloxone (1 mg/kg). The dopamine antagonist haloperidol, the cholinergic antagonist atropine, and the putative satiety factors CCK-8, bombesin, histidyl-proline diketopiperazine and calcitonin suppressed insulin-induced feeding. Naloxone, CCK-8 and bombesin significantly raised blood glucose levels following insulin induced hypoglycemia.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalPeptides
Volume2
Issue number3
DOIs
StatePublished - Jan 1 1981

Keywords

  • Anorectic peptides
  • Bombesin
  • CCK-8
  • Calcitonin
  • Histidyl-proline diketopiperazine
  • Insulin-induced feeding
  • Naloxone
  • Satiety factors

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