Abstract
Subcutaneous administration of insulin (10 U/kg) produced hypoglycemia in rats with a concomitant induction of feeding. The opiate antagonist naloxone failed to alter food ingestion following insulin administration when quantitated over a 3-hour period; however, naloxone (20 mg/kg) significantly suppressed eating during the first hour of the study. Starvation-induced feeding was markedly suppressed by relatively low doses of naloxone (1 mg/kg). The dopamine antagonist haloperidol, the cholinergic antagonist atropine, and the putative satiety factors CCK-8, bombesin, histidyl-proline diketopiperazine and calcitonin suppressed insulin-induced feeding. Naloxone, CCK-8 and bombesin significantly raised blood glucose levels following insulin induced hypoglycemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-264 |
| Number of pages | 4 |
| Journal | Peptides |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1981 |
Bibliographical note
Funding Information:We thank Julie Kneip and Martha Grace for their technical assistance and Judy Sundae for her secreterial assistance. Supported in part by Veterans Administration Research and The American Diabetes Association.
Keywords
- Anorectic peptides
- Bombesin
- CCK-8
- Calcitonin
- Histidyl-proline diketopiperazine
- Insulin-induced feeding
- Naloxone
- Satiety factors