Peptide Chronomics

Franz Halberg, Germaine Cornélissen, Erhard Haus, Samuel Zinker, Rita Jozsa, Federico Perfetto, Cristina Mag

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Chronomics is the mapping of broad time structures (chronomes). Chronobiology led to the development of chronomics, the mapping of chronomes The merits of assessing peptide chronomics are best illustrated by the facts that a peptide drug may have a major effect at one circadian stage but not at another; that a major effect on a polypeptide may be exerted again at one circadian stage but not at another; and that, by the design and the software of chronomics, relatively small numbers of patients are needed to validate such effects by inferential statistics. A great opportunity for applications of peptide chronomics lies in the pharmaceutical industry. Chronomics may find associations of certain circannual rhythmic patterns of the polypeptide prolactin with an elevated breast cancer risk, or it may find that a fixed dose of another peptide such as adrenocorticotropic hormone (ACTH) acts in one stage of a circadian system but not in another.

Original languageEnglish (US)
Title of host publicationHandbook of Biologically Active Peptides
PublisherElsevier Inc.
Number of pages36
ISBN (Print)9780123694423
StatePublished - 2006

Bibliographical note

Funding Information:
Support was provided by the U.S. Public Health Service (GM-13981) (FH).


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