Peptide amphiphile micelles for vaccine delivery

John C. Barrett, Matthew V. Tirrell

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Peptide subunit vaccines enable the specific activation of an immune response without the shortcomings of killed or attenuated pathogens. However, peptide subunit vaccines tend to be less immunogenic than those based on whole organisms. To improve peptide immunogenicity, biomaterials-based platforms have been developed. One such platform, the peptide amphiphile micelle platform, has displayed a unique ability to dramatically improve observed immune responses. Here we describe the design, synthesis, characterization, and application of peptide amphiphile micelles to elicit a robust immune response.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages277-292
Number of pages16
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1798
ISSN (Print)1064-3745

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2018.

Keywords

  • Modular
  • Peptide amphiphile micelle
  • Peptide synthesis
  • Self-assembly
  • Vaccine

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