PepCyber:P∼PEP: A database of human protein-protein interactions mediated by phosphoprotein-binding domains

Wuming Gong, Dihan Zhou, Yongliang Ren, Yejun Wang, Zhixiang Zuo, Yanping Shen, Feifei Xiao, Qi Zhu, Ailing Hong, Xiaochuan Zhou, Xiaolian Gao, Tongbin Li

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Abstract

Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P∼PEP is a newly constructed database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions. Our motivation is to provide the research community with a rich information source emphasizing the reported, experimentally validated data for specific PPBD-PPEP interactions. This information is not only useful for designing, comparing and validating the relevant experiments, but it also serves as a knowledge-base for computationally constructing systems signaling pathways and networks. PepCyber:P∼PEP is accessible through the URL, http://www.pepcyber.org/PPEP/. The current release of the database contains 7044 PPBD-mediated interactions involving 337 PPBD-containing proteins and 1123 substrate proteins.

LanguageEnglish (US)
JournalNucleic acids research
Volume36
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 2008

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Protein Databases
Phosphoproteins
Proteins
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Proteome
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PepCyber:P∼PEP : A database of human protein-protein interactions mediated by phosphoprotein-binding domains. / Gong, Wuming; Zhou, Dihan; Ren, Yongliang; Wang, Yejun; Zuo, Zhixiang; Shen, Yanping; Xiao, Feifei; Zhu, Qi; Hong, Ailing; Zhou, Xiaochuan; Gao, Xiaolian; Li, Tongbin.

In: Nucleic acids research, Vol. 36, No. SUPPL. 1, 01.01.2008.

Research output: Contribution to journalArticle

Gong, W, Zhou, D, Ren, Y, Wang, Y, Zuo, Z, Shen, Y, Xiao, F, Zhu, Q, Hong, A, Zhou, X, Gao, X & Li, T 2008, 'PepCyber:P∼PEP: A database of human protein-protein interactions mediated by phosphoprotein-binding domains' Nucleic acids research, vol. 36, no. SUPPL. 1. https://doi.org/10.1093/nar/gkm854
Gong, Wuming ; Zhou, Dihan ; Ren, Yongliang ; Wang, Yejun ; Zuo, Zhixiang ; Shen, Yanping ; Xiao, Feifei ; Zhu, Qi ; Hong, Ailing ; Zhou, Xiaochuan ; Gao, Xiaolian ; Li, Tongbin. / PepCyber:P∼PEP : A database of human protein-protein interactions mediated by phosphoprotein-binding domains. In: Nucleic acids research. 2008 ; Vol. 36, No. SUPPL. 1.
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