Immunization programs in developing tropical countries are faced with significant logistic problems. Research is oriented towards the evaluation of simultaneously administered multiple antigens which would confer maximum protection at one vaccination. The authors report the preliminary evaluation of an association of smallpox vaccine, yellow fever vaccine, measles vaccine, BCG, and tetanus toxoid administered simultaneously. The tetanus toxoid and measles vaccine were mixed just prior to immunization and given in the same injection. Standard doses of vaccine were given, except for a dose of 60 Lf of calcium adsorbed tetanus toxoid in order to provide protection after one injection of each antigen. Active surveillance of the reactions verified that the reactions following this association of antigens were the same as when the antigens were administered separately.
|Translated title of the contribution
|Pentavalent vaccine association; a preliminary study
|Number of pages
|Published - Dec 1 1973