Penile Cancer in a Man with Netherton Syndrome

Sumit Isharwal; Juan Carlos Manivel; Badrinath R Konety

doi:10.1016/j.urology.2014.12.042

Penile Cancer in a Man with Netherton Syndrome

Sumit Isharwal, Juan Carlos Manivel, Badrinath R Konety

Urology

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3 Scopus citations

Abstract

Netherton syndrome (NS) is a rare autosomal recessive skin disease with severe skin inflammation and scaling, a specific hair shaft defect (trichorrhexis invaginata or bamboo hair), and severe atopic manifestations including atopic dermatitis and hay fever with high serum immunoglobulin E levels and hypereosinophilia. NS is caused by loss-of-function mutations in serine protease inhibitor of Kazal-type 5 (SPINK5) encoding lympho-epithelial Kazal-type-related inhibitor (LEKTI) expressed in the stratified epithelia. We report the first case of penile squamous cell carcinoma in a patient with NS.

Original language	English (US)
Pages (from-to)	e21-e22
Journal	Urology
Volume	85
Issue number	4
DOIs	https://doi.org/10.1016/j.urology.2014.12.042
State	Published - Jan 1 2015

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title = "Penile Cancer in a Man with Netherton Syndrome",

abstract = "Netherton syndrome (NS) is a rare autosomal recessive skin disease with severe skin inflammation and scaling, a specific hair shaft defect (trichorrhexis invaginata or bamboo hair), and severe atopic manifestations including atopic dermatitis and hay fever with high serum immunoglobulin E levels and hypereosinophilia. NS is caused by loss-of-function mutations in serine protease inhibitor of Kazal-type 5 (SPINK5) encoding lympho-epithelial Kazal-type-related inhibitor (LEKTI) expressed in the stratified epithelia. We report the first case of penile squamous cell carcinoma in a patient with NS.",

author = "Sumit Isharwal and Manivel, {Juan Carlos} and Konety, {Badrinath R}",

year = "2015",

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T1 - Penile Cancer in a Man with Netherton Syndrome

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AU - Manivel, Juan Carlos

AU - Konety, Badrinath R

PY - 2015/1/1

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N2 - Netherton syndrome (NS) is a rare autosomal recessive skin disease with severe skin inflammation and scaling, a specific hair shaft defect (trichorrhexis invaginata or bamboo hair), and severe atopic manifestations including atopic dermatitis and hay fever with high serum immunoglobulin E levels and hypereosinophilia. NS is caused by loss-of-function mutations in serine protease inhibitor of Kazal-type 5 (SPINK5) encoding lympho-epithelial Kazal-type-related inhibitor (LEKTI) expressed in the stratified epithelia. We report the first case of penile squamous cell carcinoma in a patient with NS.

AB - Netherton syndrome (NS) is a rare autosomal recessive skin disease with severe skin inflammation and scaling, a specific hair shaft defect (trichorrhexis invaginata or bamboo hair), and severe atopic manifestations including atopic dermatitis and hay fever with high serum immunoglobulin E levels and hypereosinophilia. NS is caused by loss-of-function mutations in serine protease inhibitor of Kazal-type 5 (SPINK5) encoding lympho-epithelial Kazal-type-related inhibitor (LEKTI) expressed in the stratified epithelia. We report the first case of penile squamous cell carcinoma in a patient with NS.

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ER -

Penile Cancer in a Man with Netherton Syndrome

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