Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation.

R. L. Greenman, S. M. Arcey, G. M. Dickinson, J. E. Mokhbat, L. D. Sabath, T. B. Platt, L. T. Friedhoff

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gm intravenous dose, CSF aztreonam levels ranged from 0.76 to 16.6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1.28 mg/l, which was lower than the mean concentration of 7.2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms.
Original languageUndefined/Unknown
Pages (from-to)637-640
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume15
Issue number5
StatePublished - 1985

Keywords

  • Adult
  • Aged
  • Anti-Bacterial Agents/cf [Cerebrospinal Fluid]
  • Aztreonam
  • Female
  • Humans
  • Male
  • Meningitis/cf [Cerebrospinal Fluid]
  • Meningitis/dt [Drug Therapy]
  • Meningitis, Meningococcal/cf [Cerebrospinal Fluid]
  • Meningitis, Viral/cf [Cerebrospinal Fluid]
  • Middle Aged

Cite this

Greenman, R. L., Arcey, S. M., Dickinson, G. M., Mokhbat, J. E., Sabath, L. D., Platt, T. B., & Friedhoff, L. T. (1985). Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation. Journal of Antimicrobial Chemotherapy, 15(5), 637-640.

Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation. / Greenman, R. L.; Arcey, S. M.; Dickinson, G. M.; Mokhbat, J. E.; Sabath, L. D.; Platt, T. B.; Friedhoff, L. T.

In: Journal of Antimicrobial Chemotherapy, Vol. 15, No. 5, 1985, p. 637-640.

Research output: Contribution to journalArticle

Greenman, RL, Arcey, SM, Dickinson, GM, Mokhbat, JE, Sabath, LD, Platt, TB & Friedhoff, LT 1985, 'Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation.', Journal of Antimicrobial Chemotherapy, vol. 15, no. 5, pp. 637-640.
Greenman, R. L. ; Arcey, S. M. ; Dickinson, G. M. ; Mokhbat, J. E. ; Sabath, L. D. ; Platt, T. B. ; Friedhoff, L. T. / Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation. In: Journal of Antimicrobial Chemotherapy. 1985 ; Vol. 15, No. 5. pp. 637-640.
@article{db0881bc8e0548a28f4135f189c29d8b,
title = "Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation.",
abstract = "Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gm intravenous dose, CSF aztreonam levels ranged from 0.76 to 16.6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1.28 mg/l, which was lower than the mean concentration of 7.2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms.",
keywords = "Adult, Aged, Anti-Bacterial Agents/cf [Cerebrospinal Fluid], Aztreonam, Female, Humans, Male, Meningitis/cf [Cerebrospinal Fluid], Meningitis/dt [Drug Therapy], Meningitis, Meningococcal/cf [Cerebrospinal Fluid], Meningitis, Viral/cf [Cerebrospinal Fluid], Middle Aged",
author = "Greenman, {R. L.} and Arcey, {S. M.} and Dickinson, {G. M.} and Mokhbat, {J. E.} and Sabath, {L. D.} and Platt, {T. B.} and Friedhoff, {L. T.}",
year = "1985",
language = "Undefined/Unknown",
volume = "15",
pages = "637--640",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation.

AU - Greenman, R. L.

AU - Arcey, S. M.

AU - Dickinson, G. M.

AU - Mokhbat, J. E.

AU - Sabath, L. D.

AU - Platt, T. B.

AU - Friedhoff, L. T.

PY - 1985

Y1 - 1985

N2 - Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gm intravenous dose, CSF aztreonam levels ranged from 0.76 to 16.6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1.28 mg/l, which was lower than the mean concentration of 7.2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms.

AB - Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gm intravenous dose, CSF aztreonam levels ranged from 0.76 to 16.6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1.28 mg/l, which was lower than the mean concentration of 7.2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms.

KW - Adult

KW - Aged

KW - Anti-Bacterial Agents/cf [Cerebrospinal Fluid]

KW - Aztreonam

KW - Female

KW - Humans

KW - Male

KW - Meningitis/cf [Cerebrospinal Fluid]

KW - Meningitis/dt [Drug Therapy]

KW - Meningitis, Meningococcal/cf [Cerebrospinal Fluid]

KW - Meningitis, Viral/cf [Cerebrospinal Fluid]

KW - Middle Aged

M3 - Article

VL - 15

SP - 637

EP - 640

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 5

ER -