PELP1: A review of PELP1 interactions, signaling, and biology

Brian J. Girard; Andrea R. Daniel; Carol A. Lange; Julie H. Ostrander

doi:10.1016/j.mce.2013.07.031

PELP1: A review of PELP1 interactions, signaling, and biology

Brian J. Girard, Andrea R. Daniel, Carol A. Lange, Julie H. Ostrander

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a large multi-domain protein that has been shown to modulate an increasing number of pathways and biological processes. The first reports describing the cloning and characterization of PELP1 showed that it was an estrogen receptor coactivator. PELP1 has now been shown to be a coregulator for a growing number of transcription factors. Furthermore, recent reports have shown that PELP1 is a member of chromatin remodeling complexes. In addition to PELP1 nuclear functions, it has been shown to have cytoplasmic signaling functions as well. In the cytoplasm PELP1 acts as a scaffold molecule and mediates rapid signaling from growth factor and hormone receptors. PELP1 signaling ultimately plays a role in cancer biology by increasing proliferation and metastasis, among other cellular processes. Here we will review (1) the cloning and characterization of PELP1 expression, (2) interacting proteins, (3) PELP1 signaling, and (4) PELP1-mediated biology.

Original language	English (US)
Pages (from-to)	642-651
Number of pages	10
Journal	Molecular and Cellular Endocrinology
Volume	382
Issue number	1
DOIs	https://doi.org/10.1016/j.mce.2013.07.031
State	Published - Jan 25 2014

Bibliographical note

Funding Information:
The authors would like to recognize their funding sources: NIH/NCI R01 CA159712 (CAL), National Center for Advancing Translational Sciences of the National Institutes of Health Award UL1TR000114 (JHO), and NIH/NCI K07CA131501-02 (JHO).

Keywords

Coactivator
Estrogen signaling
Extra-nuclear signaling
Hormone resistance
PELP1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mce.2013.07.031

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abstract = "Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a large multi-domain protein that has been shown to modulate an increasing number of pathways and biological processes. The first reports describing the cloning and characterization of PELP1 showed that it was an estrogen receptor coactivator. PELP1 has now been shown to be a coregulator for a growing number of transcription factors. Furthermore, recent reports have shown that PELP1 is a member of chromatin remodeling complexes. In addition to PELP1 nuclear functions, it has been shown to have cytoplasmic signaling functions as well. In the cytoplasm PELP1 acts as a scaffold molecule and mediates rapid signaling from growth factor and hormone receptors. PELP1 signaling ultimately plays a role in cancer biology by increasing proliferation and metastasis, among other cellular processes. Here we will review (1) the cloning and characterization of PELP1 expression, (2) interacting proteins, (3) PELP1 signaling, and (4) PELP1-mediated biology.",

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author = "Girard, {Brian J.} and Daniel, {Andrea R.} and Lange, {Carol A.} and Ostrander, {Julie H.}",

note = "Funding Information: The authors would like to recognize their funding sources: NIH/NCI R01 CA159712 (CAL), National Center for Advancing Translational Sciences of the National Institutes of Health Award UL1TR000114 (JHO), and NIH/NCI K07CA131501-02 (JHO).",

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AU - Ostrander, Julie H.

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AB - Proline, glutamic acid, and leucine rich protein 1 (PELP1) is a large multi-domain protein that has been shown to modulate an increasing number of pathways and biological processes. The first reports describing the cloning and characterization of PELP1 showed that it was an estrogen receptor coactivator. PELP1 has now been shown to be a coregulator for a growing number of transcription factors. Furthermore, recent reports have shown that PELP1 is a member of chromatin remodeling complexes. In addition to PELP1 nuclear functions, it has been shown to have cytoplasmic signaling functions as well. In the cytoplasm PELP1 acts as a scaffold molecule and mediates rapid signaling from growth factor and hormone receptors. PELP1 signaling ultimately plays a role in cancer biology by increasing proliferation and metastasis, among other cellular processes. Here we will review (1) the cloning and characterization of PELP1 expression, (2) interacting proteins, (3) PELP1 signaling, and (4) PELP1-mediated biology.

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PELP1: A review of PELP1 interactions, signaling, and biology

Abstract

Bibliographical note

Keywords

UN SDGs

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