Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder

Jill L. Ostrem, Chadwick W. Christine, Graham A. Glass, Lauren E. Schrock, Philip A. Starr

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Background: Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) has recently been suggested for treatment of medication-unresponsive gait and axial symptoms in Parkinson's disease. Patients with the rare primary progressive freezing gait disorder (PPFG) have similar disabling symptoms and few therapeutic options. We report here on our experience with PPN DBS in treating a 76-year-old man with medication-refractory PPFG. Methods: The patient was treated with staged PPN DBS and underwent careful pre- and postoperative clinical evaluations up to 12 months after surgery. Results: PPN DBS resulted in only mild improvement in symptoms after 12 months of stimulation. Conclusion: In this single case of a patient with PPFG, PPN DBS served only a limited role in treating his symptoms and adds to the very limited published literature describing patients treated with DBS at this brain target.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalStereotactic and Functional Neurosurgery
Volume88
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Deep brain stimulation
  • Pedunculopontine nucleus
  • Primary progressive freezing gait

Fingerprint Dive into the research topics of 'Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder'. Together they form a unique fingerprint.

Cite this