Pediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes

Amanda K. Johnson; Sasidhar Goteti; Bar Devald; Shelby Mestnik; Taumoha Ghosh; Robin Williams; Elizabeth S. Doughty; Michael A. Linden; Amy Beckman; Todd Williams; Kelsey Richardson; Marie Martinelli

doi:10.1002/pbc.31234

Pediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes

Amanda K. Johnson, Sasidhar Goteti, Bar Devald, Shelby Mestnik, Taumoha Ghosh, Robin Williams, Elizabeth S. Doughty, Michael A. Linden, Amy Beckman, Todd Williams, Kelsey Richardson, Marie Martinelli

Research output: Contribution to journal › Article › peer-review

Abstract

A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi-institutional case series highlights the need to work toward earlier diagnosis and improved long-term management recommendations for patients with TAFRO syndrome.

Original language	English (US)
Article number	e31234
Journal	Pediatric Blood and Cancer
Volume	71
Issue number	10
DOIs	https://doi.org/10.1002/pbc.31234
State	Published - Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.

Keywords

Castleman's disease
anemia
fever
lymphoproliferative disorders
organomegaly (TAFRO) syndrome
renal dysfunction
reticulin fibrosis
thrombocytopenia

PubMed: MeSH publication types

Case Reports
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.31234

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Johnson, A. K., Goteti, S., Devald, B., Mestnik, S., Ghosh, T., Williams, R., Doughty, E. S., Linden, M. A., Beckman, A., Williams, T., Richardson, K., & Martinelli, M. (2024). Pediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes. Pediatric Blood and Cancer, 71(10), Article e31234. https://doi.org/10.1002/pbc.31234

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title = "Pediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes",

abstract = "A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi-institutional case series highlights the need to work toward earlier diagnosis and improved long-term management recommendations for patients with TAFRO syndrome.",

keywords = "Castleman's disease, anemia, fever, lymphoproliferative disorders, organomegaly (TAFRO) syndrome, renal dysfunction, reticulin fibrosis, thrombocytopenia",

author = "Johnson, {Amanda K.} and Sasidhar Goteti and Bar Devald and Shelby Mestnik and Taumoha Ghosh and Robin Williams and Doughty, {Elizabeth S.} and Linden, {Michael A.} and Amy Beckman and Todd Williams and Kelsey Richardson and Marie Martinelli",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.",

year = "2024",

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T2 - A multi-institution case series illustrating clinical challenges and excellent outcomes

AU - Johnson, Amanda K.

AU - Goteti, Sasidhar

AU - Devald, Bar

AU - Mestnik, Shelby

AU - Ghosh, Taumoha

AU - Williams, Robin

AU - Doughty, Elizabeth S.

AU - Linden, Michael A.

AU - Beckman, Amy

AU - Williams, Todd

AU - Richardson, Kelsey

AU - Martinelli, Marie

PY - 2024/10

Y1 - 2024/10

N2 - A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi-institutional case series highlights the need to work toward earlier diagnosis and improved long-term management recommendations for patients with TAFRO syndrome.

AB - A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi-institutional case series highlights the need to work toward earlier diagnosis and improved long-term management recommendations for patients with TAFRO syndrome.

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KW - anemia

KW - fever

KW - lymphoproliferative disorders

KW - organomegaly (TAFRO) syndrome

KW - renal dysfunction

KW - reticulin fibrosis

KW - thrombocytopenia

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JO - Pediatric Blood and Cancer

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ER -

Pediatric TAFRO syndrome: A multi-institution case series illustrating clinical challenges and excellent outcomes

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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