Pediatric Pharmacokinetics. Human Development and Drug Disposition.

Ryan S. Funk, Jacob T. Brown, Susan M. Abdel-Rahman

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Human development is described by the various anatomic and physiologic changes that occur as the single-celled zygote matures into an adult human being. Concomitant with bodily maturation are changes in the complex interactions between pharmacologic agents and the biologic matrix that is the human body. Profound changes in the manner by which drugs traverse the body during development can have significant implications in drug efficacy and toxicity. Although not a replacement for well-conducted, pediatric, pharmacokinetic studies, an understanding of developmental biology and the mechanisms for drug disposition invariably assists the pediatric clinician with the judicious use of medications in children.

Original languageEnglish (US)
Pages (from-to)1001-1016
Number of pages16
JournalPediatric clinics of North America
Volume59
Issue number5
DOIs
StatePublished - Oct 1 2012

Keywords

  • Absorption
  • Development
  • Distribution
  • Excretion
  • Metabolism
  • Pediatric
  • Pharmacokinetic
  • Transport

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