TY - JOUR
T1 - Pediatric cancer survivorship research
T2 - Experience of the childhood cancer survivor study
AU - Leisenring, Wendy M.
AU - Mertens, Ann C.
AU - Armstrong, Gregory T.
AU - Stovall, Marilyn A.
AU - Neglia, Joseph P.
AU - Lanctot, Jennifer Q.
AU - Boice, John D.
AU - Whitton, John A.
AU - Yasui, Yutaka
PY - 2009/5/10
Y1 - 2009/5/10
N2 - The Childhood Cancer Survivor Study (CCSS) is a comprehensive multicenter study designed to quantify and better understand the effects of pediatric cancer and its treatment on later health, including behavioral and sociodemographic outcomes. The CCSS investigators have published more than 100 articles in the scientific literature related to the study. As with any large cohort study, high standards for methodologic approaches are imperative for valid and generalizable results. In this article we describe methodological issues of study design, exposure assessment, outcome validation, and statistical analysis. Methods for handling missing data, intrafamily correlation, and competing risks analysis are addressed; each with particular relevance to pediatric cancer survivorship research. Our goal in this article is to provide a resource and reference for other researchers working in the area of long-term cancer survivorship.
AB - The Childhood Cancer Survivor Study (CCSS) is a comprehensive multicenter study designed to quantify and better understand the effects of pediatric cancer and its treatment on later health, including behavioral and sociodemographic outcomes. The CCSS investigators have published more than 100 articles in the scientific literature related to the study. As with any large cohort study, high standards for methodologic approaches are imperative for valid and generalizable results. In this article we describe methodological issues of study design, exposure assessment, outcome validation, and statistical analysis. Methods for handling missing data, intrafamily correlation, and competing risks analysis are addressed; each with particular relevance to pediatric cancer survivorship research. Our goal in this article is to provide a resource and reference for other researchers working in the area of long-term cancer survivorship.
UR - http://www.scopus.com/inward/record.url?scp=65549157503&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65549157503&partnerID=8YFLogxK
U2 - 10.1200/JCO.2008.21.1813
DO - 10.1200/JCO.2008.21.1813
M3 - Review article
C2 - 19364957
AN - SCOPUS:65549157503
SN - 0732-183X
VL - 27
SP - 2319
EP - 2327
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 14
ER -
