Pediatric brain cancers

Christen R. Elledge, Stephanie A. Terezakis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary brain tumors are the most common solid tumor malignancy in children. The majority of pediatric brain tumors are treated with maximal safe surgical resection. Adjuvant treatments include conventionally fractionated radiation therapy and systemic therapies. Radiation therapy is an effective treatment modality for many pediatric primary brain tumors but can cause significant neurologic, neuroendocrine, and neurocognitive sequelae. Stereotactic radiosurgery (SRS) is an attractive option in pediatric patients as it allows for the delivery of ablative, high-dose radiation with steep dose gradients allowing for greater sparing of the developing brain. SRS has been used in the definitive, adjuvant, and salvage settings to treat primary pediatric brain tumors. This chapter will examine the use of SRS in the treatment of pediatric low-grade glioma, medulloblastoma, ependymoma, and craniopharyngioma with a focus on technique, oncologic outcomes, and toxicity.

Original languageEnglish (US)
Title of host publicationStereotactic Radiosurgery (SRS)
Subtitle of host publicationProcedure, Results and Risks (2 Volume Set)
PublisherNova Science Publishers, Inc.
Pages505-539
Number of pages35
Volume2-2
ISBN (Electronic)9781536176803
ISBN (Print)9781536176797
StatePublished - Jun 16 2020

Bibliographical note

Publisher Copyright:
© 2020 Nova Science Publishers, Inc.

Keywords

  • Craniopharyngioma
  • Ependymoma
  • Glioma
  • Medulloblastoma
  • Pediatrics
  • Primary brain tumors
  • Stereotactic radiosurgery

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