Pediatric Acute Liver Failure

Catherine Larson-Nath; Bernadette Vitola

doi:10.1016/j.ccc.2021.11.015

Pediatric Acute Liver Failure

Catherine Larson-Nath, Bernadette Vitola

Pediatric Gastroenterology, Hepatology & Nutrition

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. Up to 50% of children with acute liver failure will never have an underlying cause found. Early identification, supportive care, and disease-directed therapy are critical. For some children liver transplantation is needed for survival, but many children will recover with appropriate therapy, without the need for transplantation. Nonetheless, overall survival is approximately 50% without liver transplantation. Opportunities for improvement in the care of children with acute liver failure still exist.

Original language	English (US)
Pages (from-to)	301-315
Number of pages	15
Journal	Critical Care Clinics
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.ccc.2021.11.015
State	Published - Apr 2022

Bibliographical note

Funding Information:
The authors have nothing to disclose.

Keywords

Acute liver failure
Pediatric
Transplant
Liver Failure, Acute/diagnosis
Risk Assessment
Humans
Liver Transplantation/adverse effects
Child

PubMed: MeSH publication types

Review
Journal Article

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10.1016/j.ccc.2021.11.015

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title = "Pediatric Acute Liver Failure",

abstract = "Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. Up to 50% of children with acute liver failure will never have an underlying cause found. Early identification, supportive care, and disease-directed therapy are critical. For some children liver transplantation is needed for survival, but many children will recover with appropriate therapy, without the need for transplantation. Nonetheless, overall survival is approximately 50% without liver transplantation. Opportunities for improvement in the care of children with acute liver failure still exist.",

keywords = "Acute liver failure, Pediatric, Transplant, Liver Failure, Acute/diagnosis, Risk Assessment, Humans, Liver Transplantation/adverse effects, Child",

author = "Catherine Larson-Nath and Bernadette Vitola",

note = "Funding Information: The authors have nothing to disclose.",

year = "2022",

month = apr,

doi = "10.1016/j.ccc.2021.11.015",

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TY - JOUR

T1 - Pediatric Acute Liver Failure

AU - Larson-Nath, Catherine

AU - Vitola, Bernadette

N1 - Funding Information: The authors have nothing to disclose.

PY - 2022/4

Y1 - 2022/4

N2 - Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. Up to 50% of children with acute liver failure will never have an underlying cause found. Early identification, supportive care, and disease-directed therapy are critical. For some children liver transplantation is needed for survival, but many children will recover with appropriate therapy, without the need for transplantation. Nonetheless, overall survival is approximately 50% without liver transplantation. Opportunities for improvement in the care of children with acute liver failure still exist.

AB - Pediatric acute liver failure is a rare process that results from many different diseases including toxin ingestion and drug overdose, infections, metabolic and genetic disorders, immune-mediated diseases, and ischemia. Up to 50% of children with acute liver failure will never have an underlying cause found. Early identification, supportive care, and disease-directed therapy are critical. For some children liver transplantation is needed for survival, but many children will recover with appropriate therapy, without the need for transplantation. Nonetheless, overall survival is approximately 50% without liver transplantation. Opportunities for improvement in the care of children with acute liver failure still exist.

KW - Acute liver failure

KW - Pediatric

KW - Transplant

KW - Liver Failure, Acute/diagnosis

KW - Risk Assessment

KW - Humans

KW - Liver Transplantation/adverse effects

KW - Child

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DO - 10.1016/j.ccc.2021.11.015

M3 - Review article

C2 - 35369949

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SN - 0749-0704

VL - 38

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JO - Critical Care Clinics

JF - Critical Care Clinics

IS - 2

ER -

Pediatric Acute Liver Failure

Abstract

Bibliographical note

Keywords

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