PD1 blockade improves survival and CD8⁺ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice

Keyphrases

• Aged Mice 100%
• Aging 20%
• CD8+ 100%
• CD8+ T Cells 60%
• Cytotoxic Activity 100%
• Dephosphorylation 20%
• Dirty Mice 20%
• Effector Function 20%
• Effector Responses 20%
• Exhausted CD8+ T Cell 20%
• Exhausted Phenotype 20%
• High Risk 20%
• Immune Response 20%
• Increased Mortality 20%
• Inflammation 100%
• Inflammatory Response 20%
• Inhibitory Receptors 40%
• Monoclonal Antibody 20%
• Multiple Pathways 20%
• Older Individuals 20%
• Programmed Death-ligand 1 (PD-L1) 100%
• Receptor Activity 20%
• SHP2 20%
• T Cell Receptor 20%
• T Cell Receptor Signaling 20%
• T Cells 20%

Immunology and Microbiology

• CD8 100%
• Cytotoxic T-Cell 80%
• Dephosphorylation 20%
• Immune Response 20%
• Immunotherapy 20%
• Inflammation Response 20%
• Monoclonal Antibody 20%
• Mouse 100%
• Programmed Cell Death 1 100%
• T Cell 20%
• T Cell Receptor 40%

Medicine and Dentistry

• CD8 Antigen 100%
• Cytotoxic T-Cell 80%
• Dephosphorylation 20%
• Immune Response 20%
• Immunotherapy 20%
• Infection 20%
• Monoclonal Antibody 20%
• Programmed Cell Death 100%
• Serositis 20%
• T Cell 20%
• T Lymphocyte Receptor 40%
• T-Cell Response 40%