Patterns of Radiation-Associated Lymphopenia in Children with Cancer

Miloš D. Miljković, Stuart A. Grossman, Xiaobu Ye, Susannah Ellsworth, Stephanie Terezakis

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Adults with cancer commonly develop severe lymphopenia two months following chemoradiation therapy, which is an independent predictor of survival. In this retrospective study of 53 children with central nervous system tumors and sarcomas, the frequency, severity, and duration of radiation-associated lymphopenia was similar to that seen in adults. Pretreatment lymphocyte counts were 1,000 cells/mm3 or greater in all patients, with 66% experiencing grade III-IV lymphopenia two months after chemoradiation. Lymphocyte counts remained significantly lower than baseline 12 months later. Further studies are needed to determine if this is also associated with poorer survival, as seen in adults.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalCancer Investigation
Volume34
Issue number1
DOIs
StatePublished - Jan 2 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Taylor and Francis Group, LLC.

Keywords

  • Brain tumors
  • Lymphopenia
  • Radiation therapy
  • Sarcomas

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