Patterns of Radiation-Associated Lymphopenia in Children with Cancer

Miloš D. Miljković; Stuart A. Grossman; Xiaobu Ye; Susannah Ellsworth; Stephanie Terezakis

doi:10.3109/07357907.2015.1086366

Patterns of Radiation-Associated Lymphopenia in Children with Cancer

Miloš D. Miljković, Stuart A. Grossman, Xiaobu Ye, Susannah Ellsworth, Stephanie Terezakis

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Adults with cancer commonly develop severe lymphopenia two months following chemoradiation therapy, which is an independent predictor of survival. In this retrospective study of 53 children with central nervous system tumors and sarcomas, the frequency, severity, and duration of radiation-associated lymphopenia was similar to that seen in adults. Pretreatment lymphocyte counts were 1,000 cells/mm³ or greater in all patients, with 66% experiencing grade III-IV lymphopenia two months after chemoradiation. Lymphocyte counts remained significantly lower than baseline 12 months later. Further studies are needed to determine if this is also associated with poorer survival, as seen in adults.

Original language	English (US)
Pages (from-to)	32-38
Number of pages	7
Journal	Cancer Investigation
Volume	34
Issue number	1
DOIs	https://doi.org/10.3109/07357907.2015.1086366
State	Published - Jan 2 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Taylor and Francis Group, LLC.

Keywords

Brain tumors
Lymphopenia
Radiation therapy
Sarcomas

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07357907.2015.1086366

http://europepmc.org/articles/pmc4782785

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abstract = "Adults with cancer commonly develop severe lymphopenia two months following chemoradiation therapy, which is an independent predictor of survival. In this retrospective study of 53 children with central nervous system tumors and sarcomas, the frequency, severity, and duration of radiation-associated lymphopenia was similar to that seen in adults. Pretreatment lymphocyte counts were 1,000 cells/mm3 or greater in all patients, with 66% experiencing grade III-IV lymphopenia two months after chemoradiation. Lymphocyte counts remained significantly lower than baseline 12 months later. Further studies are needed to determine if this is also associated with poorer survival, as seen in adults.",

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AU - Ye, Xiaobu

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AU - Terezakis, Stephanie

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Y1 - 2016/1/2

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AB - Adults with cancer commonly develop severe lymphopenia two months following chemoradiation therapy, which is an independent predictor of survival. In this retrospective study of 53 children with central nervous system tumors and sarcomas, the frequency, severity, and duration of radiation-associated lymphopenia was similar to that seen in adults. Pretreatment lymphocyte counts were 1,000 cells/mm3 or greater in all patients, with 66% experiencing grade III-IV lymphopenia two months after chemoradiation. Lymphocyte counts remained significantly lower than baseline 12 months later. Further studies are needed to determine if this is also associated with poorer survival, as seen in adults.

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KW - Radiation therapy

KW - Sarcomas

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Patterns of Radiation-Associated Lymphopenia in Children with Cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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