Patterns of infection and day care utilization and risk of childhood acute lymphoblastic leukaemia

J. P. Neglia, M. S. Linet, X. O. Shu, R. K. Severson, J. D. Potter, A. C. Mertens, W. Wen, J. H. Kersey, L. L. Robison

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83 Scopus citations


To investigate if decreased exposure to common childhood infections is associated with risk of childhood acute lymphoblastic leukaemia (ALL) we conducted a case-control study of 1842 newly diagnosed and immunophenotypically defined cases of ALL under age 15, and 1986 matched controls in the US. Data regarding day care, sibship size and common childhood infections were obtained through parental interviews. Data were analysed stratified by leukaemia lineage and separately for 'common' childhood ALL (age 2-5 years, CD19, CD10-positive). Neither attendance at day care nor time at day care was associated with risk of ALL overall or 'common' ALL. Ear infections during infancy were less common among cases, with odds ratios of 0.86, 0.83, 0.71 and 0.69 for 1, 2-4, 5+ episodes, and continuous infections respectively (trend P = 0.026). No effect of sibship size or birth interval was seen. With one exception (ear infections), these data do not support the hypothesis that a decrease in the occurrence of common childhood infection increases risk of ALL.

Original languageEnglish (US)
Pages (from-to)234-240
Number of pages7
JournalBritish Journal of Cancer
Issue number1
StatePublished - 2000

Bibliographical note

Funding Information:
Supported in part by grants CA 48051, CA 07036, and the Children’s Cancer Research Fund of the University of Minnesota. Contributing Children’s Cancer Group investigators, institutions, and grant numbers are given in the Appendix. Grant support from the Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Department of Health and Human Services.


  • Childhood acute lymphoblastic leukaemia
  • Day care
  • Infections


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