Patterns of immunohistochemistry utilization in metastases to the liver

Research output: Contribution to journalArticle

Abstract

Immunohistochemistry (IHC) is a well-established morphology adjunct enabling pathologists to make accurate diagnoses. Metastases to the liver is a common scenario where pathologists may rely heavily on IHC in their interpretation. We conducted this study to audit the patterns of IHC utilization in malignant liver biopsies in 3 practice types (academic, community, and expert) as an initial step toward developing best practice guidelines. A total of 1100 specimens were analyzed and the association between the availability of history of other malignancies and the practice type on IHC utilization was studied. Community pathologists were twice as likely to use IHC and to use more markers per case than academic pathologists or the expert pathologist. When history of another malignancy was available, pathologists were not only 1.5 times more likely to use IHC but they also used more markers per case. IHC was still deemed necessary to reach the diagnosis in 67% of cases with a given history of other malignancy. This study described several variables for consideration in our effort to develop IHC utilization guidelines and its results quantify the variance noted among practice types.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalApplied Immunohistochemistry and Molecular Morphology
Volume27
Issue number6
DOIs
StatePublished - Jul 1 2019

Fingerprint

Immunohistochemistry
Neoplasm Metastasis
Liver
Practice Guidelines
Neoplasms
Pathologists
Guidelines
Biopsy

Keywords

  • IHC algorithms
  • IHC guidelines
  • IHC utilization
  • malignant liver
  • practice patterns

PubMed: MeSH publication types

  • Journal Article

Cite this

Patterns of immunohistochemistry utilization in metastases to the liver. / Amin, Khalid; El-Rayes, Dina; Snover, Dale; Mettler, Tetyana N; Vogel, Rachel I; Khalifa, Mahmoud A.

In: Applied Immunohistochemistry and Molecular Morphology, Vol. 27, No. 6, 01.07.2019, p. 441-447.

Research output: Contribution to journalArticle

@article{35ac2d84c49f4552b210126469d85de8,
title = "Patterns of immunohistochemistry utilization in metastases to the liver",
abstract = "Immunohistochemistry (IHC) is a well-established morphology adjunct enabling pathologists to make accurate diagnoses. Metastases to the liver is a common scenario where pathologists may rely heavily on IHC in their interpretation. We conducted this study to audit the patterns of IHC utilization in malignant liver biopsies in 3 practice types (academic, community, and expert) as an initial step toward developing best practice guidelines. A total of 1100 specimens were analyzed and the association between the availability of history of other malignancies and the practice type on IHC utilization was studied. Community pathologists were twice as likely to use IHC and to use more markers per case than academic pathologists or the expert pathologist. When history of another malignancy was available, pathologists were not only 1.5 times more likely to use IHC but they also used more markers per case. IHC was still deemed necessary to reach the diagnosis in 67{\%} of cases with a given history of other malignancy. This study described several variables for consideration in our effort to develop IHC utilization guidelines and its results quantify the variance noted among practice types.",
keywords = "IHC algorithms, IHC guidelines, IHC utilization, malignant liver, practice patterns",
author = "Khalid Amin and Dina El-Rayes and Dale Snover and Mettler, {Tetyana N} and Vogel, {Rachel I} and Khalifa, {Mahmoud A}",
year = "2019",
month = "7",
day = "1",
doi = "10.1097/PAI.0000000000000643",
language = "English (US)",
volume = "27",
pages = "441--447",
journal = "Applied Immunohistochemistry and Molecular Morphology",
issn = "1541-2016",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Patterns of immunohistochemistry utilization in metastases to the liver

AU - Amin, Khalid

AU - El-Rayes, Dina

AU - Snover, Dale

AU - Mettler, Tetyana N

AU - Vogel, Rachel I

AU - Khalifa, Mahmoud A

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Immunohistochemistry (IHC) is a well-established morphology adjunct enabling pathologists to make accurate diagnoses. Metastases to the liver is a common scenario where pathologists may rely heavily on IHC in their interpretation. We conducted this study to audit the patterns of IHC utilization in malignant liver biopsies in 3 practice types (academic, community, and expert) as an initial step toward developing best practice guidelines. A total of 1100 specimens were analyzed and the association between the availability of history of other malignancies and the practice type on IHC utilization was studied. Community pathologists were twice as likely to use IHC and to use more markers per case than academic pathologists or the expert pathologist. When history of another malignancy was available, pathologists were not only 1.5 times more likely to use IHC but they also used more markers per case. IHC was still deemed necessary to reach the diagnosis in 67% of cases with a given history of other malignancy. This study described several variables for consideration in our effort to develop IHC utilization guidelines and its results quantify the variance noted among practice types.

AB - Immunohistochemistry (IHC) is a well-established morphology adjunct enabling pathologists to make accurate diagnoses. Metastases to the liver is a common scenario where pathologists may rely heavily on IHC in their interpretation. We conducted this study to audit the patterns of IHC utilization in malignant liver biopsies in 3 practice types (academic, community, and expert) as an initial step toward developing best practice guidelines. A total of 1100 specimens were analyzed and the association between the availability of history of other malignancies and the practice type on IHC utilization was studied. Community pathologists were twice as likely to use IHC and to use more markers per case than academic pathologists or the expert pathologist. When history of another malignancy was available, pathologists were not only 1.5 times more likely to use IHC but they also used more markers per case. IHC was still deemed necessary to reach the diagnosis in 67% of cases with a given history of other malignancy. This study described several variables for consideration in our effort to develop IHC utilization guidelines and its results quantify the variance noted among practice types.

KW - IHC algorithms

KW - IHC guidelines

KW - IHC utilization

KW - malignant liver

KW - practice patterns

UR - http://www.scopus.com/inward/record.url?scp=85053178748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053178748&partnerID=8YFLogxK

U2 - 10.1097/PAI.0000000000000643

DO - 10.1097/PAI.0000000000000643

M3 - Article

C2 - 30192243

AN - SCOPUS:85053178748

VL - 27

SP - 441

EP - 447

JO - Applied Immunohistochemistry and Molecular Morphology

JF - Applied Immunohistochemistry and Molecular Morphology

SN - 1541-2016

IS - 6

ER -