Patterns of functional improvement after revision knee arthroplasty

Hassan M.K. Ghomrawi, Robert L Kane, Lynn E Eberly, Boris Bershadsky, Khaled J. Saleh, Robert Bourne, Charles Clark, Gerard Engh, Terence Gioe, Steven Haas, David Heck, Richard Iorio, Craig Israelite, William Healy, Kenneth Krackow, Paul Lotke, Charles Nelson, William Macaulay, Steve MacDonald, William MihalkoMichael Mont, Cecil Rorabeck, Sean Scully, Giles Scuderi, Russell Windsor, Mathias Bostrom, Thomas Sculco, Marc F Swiontkowski

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Background: Despite the increase in the number of total knee arthroplasty revisions, outcomes of such surgery and their correlates are poorly understood. The aim of this study was to characterize patterns of functional improvement after revision total knee arthroplasty over a two-year period and to investigate factors that affect such improvement patterns. Methods: Three hundred and eight patients in need of revision surgery were enrolled into the study, conducted at seventeen centers, and 221 (71.8%) were followed for two years. Short Form-36 (SF-36), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lower-Extremity Activity Scale (LEAS) scores were collected at baseline and every six months for two years postoperatively. A piecewise general linear mixed model, which models correlation between repeated measures and estimates separate slopes for different follow-up time periods, was employed to examine functional improvement patterns. Results: Separate regression slopes were estimated for the zero to twelve-month and the twelve to twenty-four-month periods. The slopes for zero to twelve months showed significant improvement in all measures in the first year. The slopes for twelve to twenty-four months showed deterioration in the scores of the WOMAC pain subscale (slope = 0.67 ± 0.21, p < 0.01) and function subscale (slope = 1.66 ± 0.63, p < 0.05), whereas the slopes of the other measures had plateaued. A higher number of comorbidities was consistently the strongest deterrent of functional improvement across measures. The modes of failure of the primary total knee arthroplasty were instrument-specific predictors of outcome (for example, tibial bone lysis affected only the SF-36 physical component score [coefficient =25.46 ± 1.91, p < 0.01], while malalignment affected both the SF-36 physical component score [coefficient = 5.41 ± 2.35, p < 0.05] and the LEAS score [coefficient = 1.42 ± 0.69, p < 0.05]). Factors related to the surgical technique did not predict outcomes. Conclusions: The onset of worsening pain and knee-specific function in the second year following revision total knee arthroplasty indicates the need to closely monitor patients, irrespective of the mode of failure of the primary procedure or the surgical technique for the revision. This information may be especially important for patients with multiple comorbidities. Level of Evidence: Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence.

Original languageEnglish (US)
Pages (from-to)2838-2845
Number of pages8
JournalJournal of Bone and Joint Surgery - American Volume
Issue number12
StatePublished - Dec 1 2009

Bibliographical note

Funding Information:
This study was funded by the Orthopaedic Research and Education Foundation, American Geriatrics Society, and The Knee Society. Dr. Ghomrawi was also supported in part by the Weill Cornell Medical College Center for Education and Research on Therapeutics (CERT) Program from the Agency for Healthcare Research and Quality, Grant Number U18 HS016075.


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