Patterns of acute bilirubin encephalopathy in Nigeria: a multicenter pre-intervention study

*On behalf of the Stop Kernicterus In Nigeria (SKIN) study group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Acute bilirubin encephalopathy (ABE) is an important cause of neonatal morbidity in Nigeria, accounting for 5–14% of neonatal deaths. Most newborns with severe ABE have irreversible damage before receiving treatment emphasizing the need for timely pre-admission monitoring and referral. There is limited evidence that educational interventions targeting mothers and health care providers will reduce delayed care. Objective: To provide baseline data on the incidence of ABE and associated pre-admission risk factors in five centers of Nigeria in order to evaluate the effect of subsequent educational interventions on outcome. Study design: The incidence of ABE among newborns treated for hyperbilirubinemia was documented prospectively. Bivariate analysis and multivariate logistic regression were used to evaluate risk factors for acute bilirubin encephalopathy and reasons for regional differences in its occurrence. Results: Of 1040 infants, 159 treated for hyperbilirubinemia (15.3%) had mild to severe bilirubin encephalopathy (including 35 deaths), but the incidence ranged from 7 to 22% between centers. Logistic regression identified four common predictors: total serum bilirubin (odds ratio 1.007 per mg/dl rise), out-of-hospital births (OR 2.6), non-alloimmune hemolytic anemia (OR 2.8), and delayed care seeking (OR 4.3). Conclusion: The high occurrence of bilirubin encephalopathy in Nigeria is due in large part to a delay in seeking care. A planned intervention strategy will target conditions leading to severe hyperbilirubinemia and delay.

Original languageEnglish (US)
Pages (from-to)873-880
Number of pages8
JournalJournal of Perinatology
Volume38
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Kernicterus
Nigeria
Hyperbilirubinemia
Incidence
Logistic Models
Newborn Infant
Hemolytic Anemia
Bilirubin
Health Personnel
Referral and Consultation
Multivariate Analysis
Odds Ratio
Mothers
Parturition
Morbidity

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

Cite this

Patterns of acute bilirubin encephalopathy in Nigeria : a multicenter pre-intervention study. / *On behalf of the Stop Kernicterus In Nigeria (SKIN) study group.

In: Journal of Perinatology, Vol. 38, No. 7, 01.07.2018, p. 873-880.

Research output: Contribution to journalArticle

*On behalf of the Stop Kernicterus In Nigeria (SKIN) study group 2018, 'Patterns of acute bilirubin encephalopathy in Nigeria: a multicenter pre-intervention study', Journal of Perinatology, vol. 38, no. 7, pp. 873-880. https://doi.org/10.1038/s41372-018-0094-y
*On behalf of the Stop Kernicterus In Nigeria (SKIN) study group. / Patterns of acute bilirubin encephalopathy in Nigeria : a multicenter pre-intervention study. In: Journal of Perinatology. 2018 ; Vol. 38, No. 7. pp. 873-880.
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abstract = "Background: Acute bilirubin encephalopathy (ABE) is an important cause of neonatal morbidity in Nigeria, accounting for 5–14{\%} of neonatal deaths. Most newborns with severe ABE have irreversible damage before receiving treatment emphasizing the need for timely pre-admission monitoring and referral. There is limited evidence that educational interventions targeting mothers and health care providers will reduce delayed care. Objective: To provide baseline data on the incidence of ABE and associated pre-admission risk factors in five centers of Nigeria in order to evaluate the effect of subsequent educational interventions on outcome. Study design: The incidence of ABE among newborns treated for hyperbilirubinemia was documented prospectively. Bivariate analysis and multivariate logistic regression were used to evaluate risk factors for acute bilirubin encephalopathy and reasons for regional differences in its occurrence. Results: Of 1040 infants, 159 treated for hyperbilirubinemia (15.3{\%}) had mild to severe bilirubin encephalopathy (including 35 deaths), but the incidence ranged from 7 to 22{\%} between centers. Logistic regression identified four common predictors: total serum bilirubin (odds ratio 1.007 per mg/dl rise), out-of-hospital births (OR 2.6), non-alloimmune hemolytic anemia (OR 2.8), and delayed care seeking (OR 4.3). Conclusion: The high occurrence of bilirubin encephalopathy in Nigeria is due in large part to a delay in seeking care. A planned intervention strategy will target conditions leading to severe hyperbilirubinemia and delay.",
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AU - Wennberg, Richard P.

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