Patterned assembly and neurogenesis in the chick dorsal root ganglion

Lynn George, Jennifer Kasemeier-Kulesa, Branden R. Nelson, Naoko Koyano-Nakagawa, Frances Lefcort

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The birth of small-diameter TrkA+ neurons that mediate pain and thermoreception begins≈24 hours after the cessation of neural crest cell migration from progenitors residing in the nascent dorsal root ganglion. Although multiple geographically distinct progenitor pools have been proposed, this study is the first to comprehensively characterize the derivation of small-diameter neurons. In the developing chick embryo we identify novel patterns in neural crest cell migration and colonization that sculpt the incipient ganglion into a postmitotic neuronal core encapsulated by a layer of proliferative progenitor cells. Furthermore, we show that this outer progenitor layer is composed of three spatially, temporally, and molecularly distinct progenitor zones, two of which give rise to distinct populations of TrkA+ neurons.

Original languageEnglish (US)
Pages (from-to)405-422
Number of pages18
JournalJournal of Comparative Neurology
Volume518
Issue number4
DOIs
StatePublished - Feb 15 2010

Keywords

  • Dorsal root ganglion
  • Neural crest
  • Neurogenesis
  • Pax3
  • TrkA

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