Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma

Hugo V. Villar; David G. Johnson; Peter J. Lynch; Gerald D. Pond; Phillip H. Smith

doi:10.1016/0002-9610(81)90028-3

Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma

Hugo V. Villar, David G. Johnson, Peter J. Lynch, Gerald D. Pond, Phillip H. Smith

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Abstract

Gel fractionation of portal, arterial and peripheral plasma glucagon levels was performed before and after the successful removal of a glucagonoma. A 47 year old woman had symptoms of dermatitis, weight loss, anemia and diabetes mellitus over a 16 year period. Removal of the alpha-cell tumor corrected all of her symptoms. Gel filtration of portal, arterial and peripheral blood showed two peaks of glucagon radioimmunoassay activity, a higher molecular weight glucagon with a molecular weight of 9,000 and a 3,500 dalton glucagon. Five minutes after tumor removal, the higher molecular weight glucagon had disappeared completely from the arterial and peripheral blood but not from the portal vein.

Original language	English (US)
Pages (from-to)	148-152
Number of pages	5
Journal	The American Journal of Surgery
Volume	141
Issue number	1
DOIs	https://doi.org/10.1016/0002-9610(81)90028-3
State	Published - Jan 1981
Externally published	Yes

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title = "Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma",

abstract = "Gel fractionation of portal, arterial and peripheral plasma glucagon levels was performed before and after the successful removal of a glucagonoma. A 47 year old woman had symptoms of dermatitis, weight loss, anemia and diabetes mellitus over a 16 year period. Removal of the alpha-cell tumor corrected all of her symptoms. Gel filtration of portal, arterial and peripheral blood showed two peaks of glucagon radioimmunoassay activity, a higher molecular weight glucagon with a molecular weight of 9,000 and a 3,500 dalton glucagon. Five minutes after tumor removal, the higher molecular weight glucagon had disappeared completely from the arterial and peripheral blood but not from the portal vein.",

author = "Villar, {Hugo V.} and Johnson, {David G.} and Lynch, {Peter J.} and Pond, {Gerald D.} and Smith, {Phillip H.}",

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doi = "10.1016/0002-9610(81)90028-3",

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T1 - Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma

AU - Villar, Hugo V.

AU - Johnson, David G.

AU - Lynch, Peter J.

AU - Pond, Gerald D.

AU - Smith, Phillip H.

PY - 1981/1

Y1 - 1981/1

N2 - Gel fractionation of portal, arterial and peripheral plasma glucagon levels was performed before and after the successful removal of a glucagonoma. A 47 year old woman had symptoms of dermatitis, weight loss, anemia and diabetes mellitus over a 16 year period. Removal of the alpha-cell tumor corrected all of her symptoms. Gel filtration of portal, arterial and peripheral blood showed two peaks of glucagon radioimmunoassay activity, a higher molecular weight glucagon with a molecular weight of 9,000 and a 3,500 dalton glucagon. Five minutes after tumor removal, the higher molecular weight glucagon had disappeared completely from the arterial and peripheral blood but not from the portal vein.

AB - Gel fractionation of portal, arterial and peripheral plasma glucagon levels was performed before and after the successful removal of a glucagonoma. A 47 year old woman had symptoms of dermatitis, weight loss, anemia and diabetes mellitus over a 16 year period. Removal of the alpha-cell tumor corrected all of her symptoms. Gel filtration of portal, arterial and peripheral blood showed two peaks of glucagon radioimmunoassay activity, a higher molecular weight glucagon with a molecular weight of 9,000 and a 3,500 dalton glucagon. Five minutes after tumor removal, the higher molecular weight glucagon had disappeared completely from the arterial and peripheral blood but not from the portal vein.

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Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma

Abstract

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