Pattern-Generating Unimolecular Sensors: For Future Differential Sensing and Molecular Computing

Bhimsen Rout, Paul L. Bigliardi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Pattern-generating unimolecular sensors are an innovative class of analytical and computing systems that utilize inherent molecular mechanisms to create multiple optical responses in a manner similar to that in which arrays of small reporter molecules can be engineered to function as cross-reactive sensors. Pattern-generating unimolecular sensors can detect and discriminate between a wide range of chemical and biochemical analytes, and they can also be used in computation, where they function as molecular logic devices utilizing chemometric analysis. This feature article summarizes the various pattern-generating approaches and their miniaturization to a unimolecular level in the fields of differential sensing and molecular computing.

Original languageEnglish (US)
Article numberst-2016-p0798-sp
Pages (from-to)1005-1010
Number of pages6
Issue number9
StatePublished - Jun 1 2017

Bibliographical note

Publisher Copyright:
© Georg Thieme Verlag Stuttgart. New York.


  • molecular computing
  • molecular logic gates
  • nanodevice
  • pattern-based detection
  • unimolecular sensors


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