Patient-specific models of deep brain stimulation: Influence of field model complexity on neural activation predictions

Ashutosh Chaturvedi, Christopher R. Butson, Scott F. Lempka, Scott E. Cooper, Cameron C. McIntyre

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the surgical therapy of choice for medically intractable Parkinson's disease. However, quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is limited. Recently, computational models of varying levels of complexity have been used to study the neural response to DBS. The goal of this study was to evaluate the quantitative impact of incrementally incorporating increasing levels of complexity into computer models of STN DBS. Our analysis focused on the direct activation of experimentally measureable fiber pathways within the internal capsule (IC). Our model system was customized to an STN DBS patient and stimulation thresholds for activation of IC axons were calculated with electric field models that ranged from an electrostatic, homogenous, isotropic model to one that explicitly incorporated the voltage-drop and capacitance of the electrode-electrolyte interface, tissue encapsulation of the electrode, and diffusion-tensor based 3D tissue anisotropy and inhomogeneity. The model predictions were compared to experimental IC activation defined from electromyographic (EMG) recordings from eight different muscle groups in the contralateral arm and leg of the STN DBS patient. Coupled evaluation of the model and experimental data showed that the most realistic predictions of axonal thresholds were achieved with the most detailed model. Furthermore, the more simplistic neurostimulation models substantially overestimated the spatial extent of neural activation.

Original languageEnglish (US)
Pages (from-to)65-77
Number of pages13
JournalBrain Stimulation
Volume3
Issue number2
DOIs
StatePublished - Apr 2010

Bibliographical note

Funding Information:
This work was supported by grants from the National Institutes of Health ( R01 NS059736 , R21 NS050449 , F32 NS052042 ). The authors would also like to thank Jaimie Henderson for providing the 3D nuclei surfaces, Susumu Mori for providing the diffusion tensor image brain atlas, Christopher Maks and Svjetlana Miocinovic for assistance with the model simulations, and Barbara Wolgamuth for assistance with clinical threshold data collection.

Keywords

  • Parkinson's disease
  • computational modeling
  • deep brain stimulation
  • neural activation

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