Abstract
Cystic fibrosis related diabetes (CFRD) is a distinct form of diabetes that is associated with significantly increased morbidity and mortality in the CF population. The primary etiology is relative insulin insufficiency secondary to destruction of pancreatic islets, and to other factors that affect the function of the remaining beta cells. The prevalence of CFRD increases markedly with age and more than half of CF adults develop the disease. As the initial presentation of CFRD may be clinically silent, annual screening is recommended starting at least by the age of 10 with an oral glucose tolerance test (OGTT). The importance of an early diagnosis is based on the association of diabetes and abnormal glucose tolerance with worse health outcomes in patients with CF, and evidence that early treatment of diabetes improves prognosis. This review presents a concise overview of the current understanding of CFRD pathogenesis, natural history, screening and diagnosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S3-S9 |
| Journal | Journal of Cystic Fibrosis |
| Volume | 18 |
| DOIs | |
| State | Published - Oct 2019 |
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Keywords
- Cystic fibrosis
- Cystic fibrosis related diabetes
- Diagnosis
- Pathophysiology
- Screening
PubMed: MeSH publication types
- Journal Article
Cite this
Cystic fibrosis related diabetes : Pathophysiology, screening and diagnosis. / Granados, Andrea; Chan, Christine L.; Ode, Katie Larson; Moheet, Amir; Moran, Antoinette; Holl, Reinhard.
In: Journal of Cystic Fibrosis, Vol. 18, 10.2019, p. S3-S9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cystic fibrosis related diabetes
T2 - Pathophysiology, screening and diagnosis
AU - Granados, Andrea
AU - Chan, Christine L.
AU - Ode, Katie Larson
AU - Moheet, Amir
AU - Moran, Antoinette
AU - Holl, Reinhard
PY - 2019/10
Y1 - 2019/10
N2 - Cystic fibrosis related diabetes (CFRD) is a distinct form of diabetes that is associated with significantly increased morbidity and mortality in the CF population. The primary etiology is relative insulin insufficiency secondary to destruction of pancreatic islets, and to other factors that affect the function of the remaining beta cells. The prevalence of CFRD increases markedly with age and more than half of CF adults develop the disease. As the initial presentation of CFRD may be clinically silent, annual screening is recommended starting at least by the age of 10 with an oral glucose tolerance test (OGTT). The importance of an early diagnosis is based on the association of diabetes and abnormal glucose tolerance with worse health outcomes in patients with CF, and evidence that early treatment of diabetes improves prognosis. This review presents a concise overview of the current understanding of CFRD pathogenesis, natural history, screening and diagnosis.
AB - Cystic fibrosis related diabetes (CFRD) is a distinct form of diabetes that is associated with significantly increased morbidity and mortality in the CF population. The primary etiology is relative insulin insufficiency secondary to destruction of pancreatic islets, and to other factors that affect the function of the remaining beta cells. The prevalence of CFRD increases markedly with age and more than half of CF adults develop the disease. As the initial presentation of CFRD may be clinically silent, annual screening is recommended starting at least by the age of 10 with an oral glucose tolerance test (OGTT). The importance of an early diagnosis is based on the association of diabetes and abnormal glucose tolerance with worse health outcomes in patients with CF, and evidence that early treatment of diabetes improves prognosis. This review presents a concise overview of the current understanding of CFRD pathogenesis, natural history, screening and diagnosis.
KW - Cystic fibrosis
KW - Cystic fibrosis related diabetes
KW - Diagnosis
KW - Pathophysiology
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=85073665691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073665691&partnerID=8YFLogxK
U2 - 10.1016/j.jcf.2019.08.016
DO - 10.1016/j.jcf.2019.08.016
M3 - Article
C2 - 31679726
AN - SCOPUS:85073665691
VL - 18
SP - S3-S9
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
ER -