Pathophysiology of coronary artery restenosis

Robert S. Schwartz, Timothy D. Henry

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


All forms of percutaneous coronary intervention confer injury on the vessel. The arterial response to that injury is the basis for long-term outcome. The stent prevents remodeling but enhances neointimal formation, and it is this neointima that is principally responsible for in-stent restenosis. Neointima forms in response to thrombus, inflammation, intimal and medial dissections, and elastic recoil of the arterial wall when a stent is not placed. Current efforts to solve restenosis center on limiting neointimal hyperplasia through drug-eluting stents and vascular brachytherapy. This article reviews arterial injury during revascularization in both patients and animal models and discusses the nature and formation of neointimal hyperplasia.

Original languageEnglish (US)
Pages (from-to)S4-S9
JournalReviews in Cardiovascular Medicine
Issue numberSUPPL. 5
StatePublished - 2002
Externally publishedYes


  • Coronary artery
  • Neointima
  • Restenosis
  • Stents
  • Thrombus


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