Pathology consultation on electronic crossmatch

Marshall A. Mazepa, Jay S. Raval, Yara A. Park, Education Committee of the Academy of Clinical Laboratory Physicians and Scientists

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Objectives: The full crossmatch is traditionally the final step in compatibility testing, acting as a serologic double check for ABO compatibility and unexpected RBC antibodies. In this review, we discuss the development of electronic crossmatch (EXM), an approach for determining when EXM can be used, and its strengths and weaknesses. Methods: Because EXM relies on highly sensitive screening assays, antibodies are frequently encountered whose clinical significance must be investigated and interpreted. Our approach is to obtain further history, perform enhanced tube testing, and consider tests of immune reactivity or RBC survival. Results: For those without clinically significant antibodies, we found two alternatives: immediate-spin crossmatch (IS XM) and EXM. IS XM is prone to error related to serologic interference, whereas EXM depends on the accuracy of the sample label, accurate data entry, and informatics to avoid errors. Conclusion: EXM is an alternative to the serologic test in patients who have no clinically significant antibodies.

Original languageEnglish (US)
Pages (from-to)618-624
Number of pages7
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - May 1 2014

Bibliographical note

Publisher Copyright:
© American Society for Clinical Pathology.


  • Crossmatch
  • EXM
  • Electronic crossmatch


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