Pathogenesis of the granulomatous lung diseases

G. W. Hunninghake, K. C. Garrett, H. B. Richerson, J. C. Fantone, P. A. Ward, S. I. Rennard, P. B. Bitterman, R. G. Crystal

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations

Abstract

The process of granuloma formation in the lung is triggered, in most instances, by exposure to an antigenic stimulus. Although the numbers of many types of cells are increased in the lung, the antigen exposure leads, primarily, to an increase in the numbers of macrophages and T-lymphocytes. This increase in the numbers of macrophages and T-cells as well as their activation provides the appropriate environment for granuloma formation.

Original languageEnglish (US)
Pages (from-to)476-496
Number of pages21
JournalAmerican Review of Respiratory Disease
Volume130
Issue number3
StatePublished - 1984

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