Pathogenesis of porcine parvovirus infection: Pathology and immunofluorescence in the foetus

H. S. Joo, C. R. Donaldson-Wood, R. H. Johnson, R. S.F. Campbell

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Porcine foetuses of dams experimentally infected with porcine parvovirus (PPV) showed differing histopathological and immunofluorescent characteristics dependent on gestational age. Histopathological changes without immunofluorescence were evident in foetuses which had passed the stage of immunocompetence, whilst less obvious histopathological changes with significant antigen fluorescence were present in foetuses which had not reached immunocompetence. Such fluorescence was evident in the parenchyma of lung, liver and kidney, and in neurons and vascular endothelium of the cerebrum. Histopathological changes consisted of some vasculitis, perivascular infiltrations and meningitis of the brain, interstitial hepatitis, interstitial nephritis and placentitis with calcification.

Original languageEnglish (US)
Pages (from-to)383-391
Number of pages9
JournalJournal of Comparative Pathology
Issue number3
StatePublished - Jul 1977

Bibliographical note

Funding Information:
We wish to thank Messrs L. R. Reilly and P. Verrall pathology. This work was funded by the Australian Committee.


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