Pathogenesis of immune-mediated carditis in monkeys.

I. S. Anand; N. K. Ganguly; A. K. Khanna; R. N. Chakravarti; P. L. Wahi

doi:10.1007/978-1-4757-4441-5_19

Pathogenesis of immune-mediated carditis in monkeys.

I. S. Anand, N. K. Ganguly, A. K. Khanna, R. N. Chakravarti, P. L. Wahi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An experimental model of carditis has been produced in the rhesus monkey by giving 12 weekly injections of streptococcal membrane antigen. Carditis was produced in as short a period as 14 weeks. There was evidence of myocarditis, endocarditis, and, in two animals, myocardial granuloma formation. No valvular lesions were seen. Measurement of immune responses showed that heart cross-reactive antibodies started appearing in the circulation after the second injection. By the sixth injection, there was evidence of complement consumption and appearance of circulating immune complexes. Antibody-dependent cell cytotoxicity started operating after the second injection, and by the sixth injection, peripheral lymphocytes had acquired hypersensitivity to membrane antigen. It is concluded that some of these immunologic responses might have played a role in the genesis of carditis.

Original language	English (US)
Pages (from-to)	215-226
Number of pages	12
Journal	Advances in myocardiology
Volume	4
DOIs	https://doi.org/10.1007/978-1-4757-4441-5_19
State	Published - 1983

Publisher link

10.1007/978-1-4757-4441-5_19

Find It

Find It at U of M Libraries

Cite this

@article{057cf78966e14530bb708aa303ce3341,

title = "Pathogenesis of immune-mediated carditis in monkeys.",

abstract = "An experimental model of carditis has been produced in the rhesus monkey by giving 12 weekly injections of streptococcal membrane antigen. Carditis was produced in as short a period as 14 weeks. There was evidence of myocarditis, endocarditis, and, in two animals, myocardial granuloma formation. No valvular lesions were seen. Measurement of immune responses showed that heart cross-reactive antibodies started appearing in the circulation after the second injection. By the sixth injection, there was evidence of complement consumption and appearance of circulating immune complexes. Antibody-dependent cell cytotoxicity started operating after the second injection, and by the sixth injection, peripheral lymphocytes had acquired hypersensitivity to membrane antigen. It is concluded that some of these immunologic responses might have played a role in the genesis of carditis.",

author = "Anand, {I. S.} and Ganguly, {N. K.} and Khanna, {A. K.} and Chakravarti, {R. N.} and Wahi, {P. L.}",

year = "1983",

doi = "10.1007/978-1-4757-4441-5_19",

language = "English (US)",

volume = "4",

pages = "215--226",

journal = "Advances in myocardiology",

issn = "0270-4056",

publisher = "Plenum Publishers",

}

TY - JOUR

T1 - Pathogenesis of immune-mediated carditis in monkeys.

AU - Anand, I. S.

AU - Ganguly, N. K.

AU - Khanna, A. K.

AU - Chakravarti, R. N.

AU - Wahi, P. L.

PY - 1983

Y1 - 1983

N2 - An experimental model of carditis has been produced in the rhesus monkey by giving 12 weekly injections of streptococcal membrane antigen. Carditis was produced in as short a period as 14 weeks. There was evidence of myocarditis, endocarditis, and, in two animals, myocardial granuloma formation. No valvular lesions were seen. Measurement of immune responses showed that heart cross-reactive antibodies started appearing in the circulation after the second injection. By the sixth injection, there was evidence of complement consumption and appearance of circulating immune complexes. Antibody-dependent cell cytotoxicity started operating after the second injection, and by the sixth injection, peripheral lymphocytes had acquired hypersensitivity to membrane antigen. It is concluded that some of these immunologic responses might have played a role in the genesis of carditis.

AB - An experimental model of carditis has been produced in the rhesus monkey by giving 12 weekly injections of streptococcal membrane antigen. Carditis was produced in as short a period as 14 weeks. There was evidence of myocarditis, endocarditis, and, in two animals, myocardial granuloma formation. No valvular lesions were seen. Measurement of immune responses showed that heart cross-reactive antibodies started appearing in the circulation after the second injection. By the sixth injection, there was evidence of complement consumption and appearance of circulating immune complexes. Antibody-dependent cell cytotoxicity started operating after the second injection, and by the sixth injection, peripheral lymphocytes had acquired hypersensitivity to membrane antigen. It is concluded that some of these immunologic responses might have played a role in the genesis of carditis.

UR - http://www.scopus.com/inward/record.url?scp=0020651158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020651158&partnerID=8YFLogxK

U2 - 10.1007/978-1-4757-4441-5_19

DO - 10.1007/978-1-4757-4441-5_19

M3 - Article

C2 - 6602357

AN - SCOPUS:0020651158

SN - 0270-4056

VL - 4

SP - 215

EP - 226

JO - Advances in myocardiology

JF - Advances in myocardiology

ER -

Pathogenesis of immune-mediated carditis in monkeys.

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this