Pathogenesis of cachexia in cancer. A review and a hypothesis

Athanasios Theologides

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


The clinical features of cachexia characterized by anorexia, marked asthenia, significant loss of body fat, protein and other components, anemia, water and electrolyte abnormalities and increased basal metabolic rate and energy expenditure despite the reduced dietary intake are just the most obvious manifestations of a profound systemic derangement of the host metabolism. A hypothesis to explain the pathogenesis of cancer cachexia is proposed.

Original languageEnglish (US)
Pages (from-to)484-488
Number of pages5
Issue number2
StatePublished - Feb 1972
Externally publishedYes

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Copyright 2016 Elsevier B.V., All rights reserved.


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